DegronMD

Uniprot ID: Q9UP65

Source protein: Cytosolic phospholipase A2 gamma

Source gene: PLA2G4C

Class: DEG_APCC_DBOX_1

Location: 377:385

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8272

ASA_SCORE: 48.8556

COIL: 0.349

CONS_SCORE: 0.3763

DSS_SCORE: 0.1302

HELIX: 0.0369

FCONS_SCORE: 1.2655

RIG_SCORE: 0.8005

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R378L	DO37851	SKCM	ICGC	SRKHLHLVD	DEG_APCC_DBOX_1	0.8428
p.M385K	TCGA-NJ-A55A	LUAD	TCGA	SRKHLHLVD	DEG_APCC_DBOX_1	0.8062
p.G379V	TCGA-55-A490	LUAD	TCGA	SRKHLHLVD	DEG_APCC_DBOX_1	0.7532
p.I380N	SIDM02063	Colorectal Carcinoma	GDSC	SRKHLHLVD	DEG_APCC_DBOX_1	0.728
p.G379D	TCGA-NH-A5IV	COAD	TCGA	SRKHLHLVD	DEG_APCC_DBOX_1	0.7198
p.S377I	NB17	autonomic_ganglia	COSMIC	SRKHLHLVD	DEG_APCC_DBOX_1	0.623
p.Y375C	TCGA-AA-A010	COAD	TCGA	SRKHLHLVD	DEG_APCC_DBOX_1	0.2778
p.Y375C	SIDM00217	Colorectal Carcinoma	GDSC	SRKHLHLVD	DEG_APCC_DBOX_1	0.2778
p.Y375C	ACH-000999	Colon/Colorectal Cancer	CCLE	SRKHLHLVD	DEG_APCC_DBOX_1	0.2778
p.Y375C	SNU-1040	large_intestine	COSMIC	SRKHLHLVD	DEG_APCC_DBOX_1	0.2778
p.M375K	DO218945	LUAD	ICGC	SRKHLHLVD	DEG_APCC_DBOX_1	0.2778
p.S387I	SIDM00255	Neuroblastoma	GDSC	SRKHLHLVD	DEG_APCC_DBOX_1	0.2778
p.S387I	ACH-002282	Neuroblastoma	CCLE	SRKHLHLVD	DEG_APCC_DBOX_1	0.2778
p.S387I	NB17	autonomic_ganglia	COSMIC	SRKHLHLVD	DEG_APCC_DBOX_1	0.2778
p.R388L	TCGA-EE-A2MD	SKCM	TCGA	SRKHLHLVD	DEG_APCC_DBOX_1	0.25
p.R388Q	TCGA-W5-AA31	CHOL	TCGA	SRKHLHLVD	DEG_APCC_DBOX_1	0.25
p.A389V	DO222632	MELA	ICGC	SRKHLHLVD	DEG_APCC_DBOX_1	0.2222
p.I390V	DO48589	LIHC	ICGC	SRKHLHLVD	DEG_APCC_DBOX_1	0.1944
p.G369D	DO49095	COAD	ICGC	SRKHLHLVD	DEG_APCC_DBOX_1	0.1111
p.P393A	DO51037	LAML	ICGC	SRKHLHLVD	DEG_APCC_DBOX_1	0.1111
p.G369V	DO24596	LUAD	ICGC	SRKHLHLVD	DEG_APCC_DBOX_1	0.1111
p.H367N	DO229034	LICA	ICGC	SRKHLHLVD	DEG_APCC_DBOX_1	0.0556

Showing 1 to 22 of 22 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UP65	Cytosolic phospholipase A2 gamma	DEG_APCC_DBOX_1	377:385	SRKHLHLVD	APC,CDC20,FZR1	0.8272	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons