DegronMD - Q9UPM6(LHX6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.W295R	TCGA-EA-A3HS	CESC	TCGA	IHYTPFSS	DEG_SCF_FBW7_1	301:308	Mutation rewiring degron network	0.1667
p.R310S	DO228978	LICA	ICGC	IHYTPFSS	DEG_SCF_FBW7_1	301:308	Mutation rewiring degron network	0.2778
p.Q298K	DO229029	LICA	ICGC	IHYTPFSS	DEG_SCF_FBW7_1	301:308	Mutation rewiring degron network	0.25
p.P312L	DO220896	MELA	ICGC	IHYTPFSS	DEG_SCF_FBW7_1	301:308	Mutation rewiring degron network	0.2222
p.P300T	DO51474	PACA	ICGC	IHYTPFSS	DEG_SCF_FBW7_1	301:308	Mutation rewiring degron network	0.3056
p.L315M	DO41644	UCEC	ICGC	IHYTPFSS	DEG_SCF_FBW7_1	301:308	Mutation rewiring degron network	0.1389
p.A317T	SIDM00946	T-Lymphoblastic Leukemia	GDSC	IHYTPFSS	DEG_SCF_FBW7_1	301:308	Mutation rewiring degron network	0.0833
p.A317T	ACH-000981	Leukemia	CCLE	IHYTPFSS	DEG_SCF_FBW7_1	301:308	Mutation rewiring degron network	0.0833
p.A317T	DND-41	haematopoietic and lymphoid tissue	COSMIC	IHYTPFSS	DEG_SCF_FBW7_1	301:308	Mutation rewiring degron network	0.0833
p.D317E	NCI-H2135	lung	COSMIC	IHYTPFSS	DEG_SCF_FBW7_1	301:308	Mutation rewiring degron network	0.0833
p.D317E	DBTRG-05MG	central nervous system	COSMIC	IHYTPFSS	DEG_SCF_FBW7_1	301:308	Mutation rewiring degron network	0.0833
p.D317N	SNU-81	large intestine	COSMIC	IHYTPFSS	DEG_SCF_FBW7_1	301:308	Mutation rewiring degron network	0.0833
p.A306T	DND-41	haematopoietic and lymphoid tissue	COSMIC	IHYTPFSS	DEG_SCF_FBW7_1	301:308	Mutation altering degron motif	0.7139
p.D299E	DBTRG-05MG	central nervous system	COSMIC	IHYTPFSS	DEG_SCF_FBW7_1	301:308	Mutation rewiring degron network	0.2778
p.D299E	NCI-H2135	lung	COSMIC	IHYTPFSS	DEG_SCF_FBW7_1	301:308	Mutation rewiring degron network	0.2778
p.D299N	SNU-81	large intestine	COSMIC	IHYTPFSS	DEG_SCF_FBW7_1	301:308	Mutation rewiring degron network	0.2778

Kaplan plot for LHX6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LHX6

UniProt ID: Q9UPM6

Entrez ID: 26468

Protein name: LIM/homeobox protein Lhx6 (LIM homeobox protein 6) (LIM/homeobox protein Lhx6.1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LHX6 in