DegronMD

Uniprot ID: Q9UPM6

Source protein: LIM/homeobox protein Lhx6

Source gene: LHX6

Class: DEG_SCF_FBW7_1

Location: 301:308

E3 ligase: FBXW7

DEGRON score: 0.993

ASA_SCORE: 67.8875

COIL: 0.89

CONS_SCORE: 0.5512

DSS_SCORE: 0.4927

HELIX: 0.061

FCONS_SCORE: 1.084

RIG_SCORE: 0.7151

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W295R	TCGA-EA-A3HS	CESC	TCGA	IHYTPFSS	DEG_SCF_FBW7_1	0.1667
p.R310S	DO228978	LICA	ICGC	IHYTPFSS	DEG_SCF_FBW7_1	0.2778
p.Q298K	DO229029	LICA	ICGC	IHYTPFSS	DEG_SCF_FBW7_1	0.25
p.P312L	DO220896	MELA	ICGC	IHYTPFSS	DEG_SCF_FBW7_1	0.2222
p.P300T	DO51474	PACA	ICGC	IHYTPFSS	DEG_SCF_FBW7_1	0.3056
p.L315M	DO41644	UCEC	ICGC	IHYTPFSS	DEG_SCF_FBW7_1	0.1389
p.A317T	SIDM00946	T-Lymphoblastic Leukemia	GDSC	IHYTPFSS	DEG_SCF_FBW7_1	0.0833
p.A317T	ACH-000981	Leukemia	CCLE	IHYTPFSS	DEG_SCF_FBW7_1	0.0833
p.A317T	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	IHYTPFSS	DEG_SCF_FBW7_1	0.0833
p.D317E	NCI-H2135	lung	COSMIC	IHYTPFSS	DEG_SCF_FBW7_1	0.0833
p.D317E	DBTRG-05MG	central_nervous_system	COSMIC	IHYTPFSS	DEG_SCF_FBW7_1	0.0833
p.D317N	SNU-81	large_intestine	COSMIC	IHYTPFSS	DEG_SCF_FBW7_1	0.0833
p.A306T	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	IHYTPFSS	DEG_SCF_FBW7_1	0.7139
p.D299E	DBTRG-05MG	central_nervous_system	COSMIC	IHYTPFSS	DEG_SCF_FBW7_1	0.2778
p.D299E	NCI-H2135	lung	COSMIC	IHYTPFSS	DEG_SCF_FBW7_1	0.2778
p.D299N	SNU-81	large_intestine	COSMIC	IHYTPFSS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPM6	LIM/homeobox protein Lhx6	DEG_SCF_FBW7_1	301:308	IHYTPFSS	FBXW7	0.993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons