DegronMD - Q9UPZ3(HPS5)

HPS5

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.C727Y	TCGA-A5-A0G1	UCEC	TCGA	PRESLDDLF	DEG_APCC_DBOX_1	713:721	Mutation rewiring degron network	0.1667
p.A728T	TCGA-A5-A0G2	UCEC	TCGA	PRESLDDLF	DEG_APCC_DBOX_1	713:721	Mutation rewiring degron network	0.1389
p.S731G	TCGA-A8-A07C	BRCA	TCGA	PRESLDDLF	DEG_APCC_DBOX_1	713:721	Mutation rewiring degron network	0.0556
p.P726Q	TCGA-D3-A2JD	SKCM	TCGA	PRESLDDLF	DEG_APCC_DBOX_1	713:721	Mutation rewiring degron network	0.1944
p.S725F	TCGA-W3-AA1V	SKCM	TCGA	PRESLDDLF	DEG_APCC_DBOX_1	713:721	Mutation blocking phosphorylation signal	0.6667
p.T718K	DO228985	LICA	ICGC	PRESLDDLF	DEG_APCC_DBOX_1	713:721	Mutation altering degron motif	0.7306
p.P717T	DO229019	LICA	ICGC	PRESLDDLF	DEG_APCC_DBOX_1	713:721	Mutation altering degron motif	0.7031
p.V707L	DO24556	LUAD	ICGC	PRESLDDLF	DEG_APCC_DBOX_1	713:721	Mutation rewiring degron network	0.1667
p.K721N	DO41235	UCEC	ICGC	PRESLDDLF	DEG_APCC_DBOX_1	713:721	Mutation altering degron motif	0.6918
p.E712G	LU-165	lung	COSMIC	PRESLDDLF	DEG_APCC_DBOX_1	713:721	Mutation blocking phosphorylation signal	0.75

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*NOTE: the Kaplan plots were collected from OncoLnc