DegronMD

Uniprot ID: Q9UPZ3

Source protein: Hermansky-Pudlak syndrome 5 protein

Source gene: HPS5

Class: DEG_APCC_DBOX_1

Location: 713:721

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.581

ASA_SCORE: 76.6889

COIL: 0.5357

CONS_SCORE: 0.3923

DSS_SCORE: 0.0782

HELIX: 0.3438

FCONS_SCORE: 0.9955

RIG_SCORE: 0.8097

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C727Y	TCGA-A5-A0G1	UCEC	TCGA	PRESLDDLF	DEG_APCC_DBOX_1	0.1667
p.A728T	TCGA-A5-A0G2	UCEC	TCGA	PRESLDDLF	DEG_APCC_DBOX_1	0.1389
p.S731G	TCGA-A8-A07C	BRCA	TCGA	PRESLDDLF	DEG_APCC_DBOX_1	0.0556
p.P726Q	TCGA-D3-A2JD	SKCM	TCGA	PRESLDDLF	DEG_APCC_DBOX_1	0.1944
p.S725F	TCGA-W3-AA1V	SKCM	TCGA	PRESLDDLF	DEG_APCC_DBOX_1	0.6667
p.T718K	DO228985	LICA	ICGC	PRESLDDLF	DEG_APCC_DBOX_1	0.7306
p.P717T	DO229019	LICA	ICGC	PRESLDDLF	DEG_APCC_DBOX_1	0.7031
p.V707L	DO24556	LUAD	ICGC	PRESLDDLF	DEG_APCC_DBOX_1	0.1667
p.K721N	DO41235	UCEC	ICGC	PRESLDDLF	DEG_APCC_DBOX_1	0.6918
p.E712G	LU-165	lung	COSMIC	PRESLDDLF	DEG_APCC_DBOX_1	0.75

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPZ3	Hermansky-Pudlak syndrome 5 protein	DEG_APCC_DBOX_1	713:721	PRESLDDLF	APC,CDC20,FZR1	0.581	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons