DegronMD - Q9UQ16(DNM3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E641Q	TCGA-CN-4734	HNSC	TCGA	RAGVYPD	LIG_APCC_ABBAyCdc20_2	628:634	Mutation rewiring degron network	0.1389
p.E641Q	DO15446	HNSC	ICGC	RAGVYPD	LIG_APCC_ABBAyCdc20_2	628:634	Mutation rewiring degron network	0.1389
p.Q639R	TCGA-D3-A2JF	SKCM	TCGA	RAGVYPD	LIG_APCC_ABBAyCdc20_2	628:634	Mutation rewiring degron network	0.1944
p.Q639R	DO38153	SKCM	ICGC	RAGVYPD	LIG_APCC_ABBAyCdc20_2	628:634	Mutation rewiring degron network	0.1944
p.A640T	TCGA-D3-A2JF	SKCM	TCGA	RAGVYPD	LIG_APCC_ABBAyCdc20_2	628:634	Mutation rewiring degron network	0.1667
p.A640T	DO38153	SKCM	ICGC	RAGVYPD	LIG_APCC_ABBAyCdc20_2	628:634	Mutation rewiring degron network	0.1667
p.N630T	TCGA-DI-A1NO	UCEC	TCGA	RAGVYPD	LIG_APCC_ABBAyCdc20_2	628:634	Mutation altering degron motif	0.7055
p.N630T	DO41662	UCEC	ICGC	RAGVYPD	LIG_APCC_ABBAyCdc20_2	628:634	Mutation altering degron motif	0.7055
p.D635N	TCGA-EB-A85J	SKCM	TCGA	RAGVYPD	LIG_APCC_ABBAyCdc20_2	628:634	Mutation rewiring degron network	0.3056
p.D635N	DO50297	SKCM	ICGC	RAGVYPD	LIG_APCC_ABBAyCdc20_2	628:634	Mutation rewiring degron network	0.3056
p.A619T	TCGA-EE-A29L	SKCM	TCGA	RAGVYPD	LIG_APCC_ABBAyCdc20_2	628:634	Mutation rewiring degron network	0.0833
p.A619T	DO222599	MELA	ICGC	RAGVYPD	LIG_APCC_ABBAyCdc20_2	628:634	Mutation rewiring degron network	0.0833
p.A619T	DO37835	SKCM	ICGC	RAGVYPD	LIG_APCC_ABBAyCdc20_2	628:634	Mutation rewiring degron network	0.0833
p.G628A	TCGA-EE-A2GJ	SKCM	TCGA	RAGVYPD	LIG_APCC_ABBAyCdc20_2	628:634	Mutation altering degron motif	0.754
p.G628A	DO37746	SKCM	ICGC	RAGVYPD	LIG_APCC_ABBAyCdc20_2	628:634	Mutation altering degron motif	0.754
p.C635R	DO548	BLCA	ICGC	RAGVYPD	LIG_APCC_ABBAyCdc20_2	628:634	Mutation rewiring degron network	0.3056
p.K636N	DO8159	COAD	ICGC	RAGVYPD	LIG_APCC_ABBAyCdc20_2	628:634	Mutation rewiring degron network	0.2778
p.L633F	DO7783	COAD	ICGC	RAGVYPD	LIG_APCC_ABBAyCdc20_2	628:634	Mutation altering degron motif	0.6981
p.L633I	DO8730	COAD	ICGC	RAGVYPD	LIG_APCC_ABBAyCdc20_2	628:634	Mutation altering degron motif	0.7174
p.N637H	DO9876	COAD	ICGC	RAGVYPD	LIG_APCC_ABBAyCdc20_2	628:634	Mutation rewiring degron network	0.25
p.W630C	DO23043	LIHC	ICGC	RAGVYPD	LIG_APCC_ABBAyCdc20_2	628:634	Mutation altering degron motif	0.7
p.P623A	DO25797	LUAD	ICGC	RAGVYPD	LIG_APCC_ABBAyCdc20_2	628:634	Mutation substituting flanking lysine	0.3056
p.E636K	DO232058	ORCA	ICGC	RAGVYPD	LIG_APCC_ABBAyCdc20_2	628:634	Mutation rewiring degron network	0.2778
p.V619I	SIDM00958	Chronic Myelogenous Leukemia	GDSC	RAGVYPD	LIG_APCC_ABBAyCdc20_2	628:634	Mutation rewiring degron network	0.0833

Kaplan plot for DNM3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DNM3

UniProt ID: Q9UQ16

Entrez ID: 26052

Protein name: Dynamin-3 (EC 3.6.5.5) (Dynamin, testicular) (T-dynamin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DNM3 in