DegronMD

Uniprot ID: Q9UQ16

Source protein: Dynamin-3

Source gene: DNM3

Class: LIG_APCC_ABBAyCdc20_2

Location: 628:634

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9976

ASA_SCORE: 70.2714

COIL: 0.745

CONS_SCORE: 0.7809

DSS_SCORE: 0.3312

HELIX: 0.164

FCONS_SCORE: 1.4385

RIG_SCORE: 0.7368

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G628A	TCGA-EE-A2GJ	SKCM	TCGA	RAGVYPD	LIG_APCC_ABBAyCdc20_2	0.754
p.G628A	DO37746	SKCM	ICGC	RAGVYPD	LIG_APCC_ABBAyCdc20_2	0.754
p.L633I	DO8730	COAD	ICGC	RAGVYPD	LIG_APCC_ABBAyCdc20_2	0.7174
p.N630T	TCGA-DI-A1NO	UCEC	TCGA	RAGVYPD	LIG_APCC_ABBAyCdc20_2	0.7055
p.N630T	DO41662	UCEC	ICGC	RAGVYPD	LIG_APCC_ABBAyCdc20_2	0.7055
p.W630C	DO23043	LIHC	ICGC	RAGVYPD	LIG_APCC_ABBAyCdc20_2	0.7
p.L633F	DO7783	COAD	ICGC	RAGVYPD	LIG_APCC_ABBAyCdc20_2	0.6981
p.D635N	TCGA-EB-A85J	SKCM	TCGA	RAGVYPD	LIG_APCC_ABBAyCdc20_2	0.3056
p.D635N	DO50297	SKCM	ICGC	RAGVYPD	LIG_APCC_ABBAyCdc20_2	0.3056
p.C635R	DO548	BLCA	ICGC	RAGVYPD	LIG_APCC_ABBAyCdc20_2	0.3056
p.P623A	DO25797	LUAD	ICGC	RAGVYPD	LIG_APCC_ABBAyCdc20_2	0.3056
p.K636N	DO8159	COAD	ICGC	RAGVYPD	LIG_APCC_ABBAyCdc20_2	0.2778
p.E636K	DO232058	ORCA	ICGC	RAGVYPD	LIG_APCC_ABBAyCdc20_2	0.2778
p.N637H	DO9876	COAD	ICGC	RAGVYPD	LIG_APCC_ABBAyCdc20_2	0.25
p.Q639R	TCGA-D3-A2JF	SKCM	TCGA	RAGVYPD	LIG_APCC_ABBAyCdc20_2	0.1944
p.Q639R	DO38153	SKCM	ICGC	RAGVYPD	LIG_APCC_ABBAyCdc20_2	0.1944
p.A640T	TCGA-D3-A2JF	SKCM	TCGA	RAGVYPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.A640T	DO38153	SKCM	ICGC	RAGVYPD	LIG_APCC_ABBAyCdc20_2	0.1667
p.E641Q	TCGA-CN-4734	HNSC	TCGA	RAGVYPD	LIG_APCC_ABBAyCdc20_2	0.1389
p.E641Q	DO15446	HNSC	ICGC	RAGVYPD	LIG_APCC_ABBAyCdc20_2	0.1389
p.A619T	TCGA-EE-A29L	SKCM	TCGA	RAGVYPD	LIG_APCC_ABBAyCdc20_2	0.0833
p.A619T	DO222599	MELA	ICGC	RAGVYPD	LIG_APCC_ABBAyCdc20_2	0.0833
p.A619T	DO37835	SKCM	ICGC	RAGVYPD	LIG_APCC_ABBAyCdc20_2	0.0833
p.V619I	SIDM00958	Chronic Myelogenous Leukemia	GDSC	RAGVYPD	LIG_APCC_ABBAyCdc20_2	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UQ16	Dynamin-3	LIG_APCC_ABBAyCdc20_2	628:634	RAGVYPD	APC,CDC20,FZR1	0.9976	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons