DegronMD - Q9UQ72(PSG11)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L144M	TCGA-05-4427	LUAD	TCGA	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.5999
p.L144M	DO23666	LUAD	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.5999
p.T146I	TCGA-44-7662	LUAD	TCGA	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.7078
p.T146I	DO23597	LUAD	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.7078
p.S152Y	TCGA-49-4505	LUAD	TCGA	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.2778
p.S152Y	DO25498	LUAD	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.2778
p.P158A	TCGA-61-2113	OV	TCGA	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1111
p.P158A	DO29328	OV	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1111
p.R159M	TCGA-73-4658	LUAD	TCGA	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.0833
p.R159M	DO23663	LUAD	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.0833
p.E145Q	TCGA-76-4934	GBM	TCGA	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.5633
p.E145Q	DO12286	GBM	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.5633
p.P147H	TCGA-A5-A0G2	UCEC	TCGA	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.7694
p.P147H	DO41235	UCEC	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.7694
p.T135N	TCGA-A5-A0G2	UCEC	TCGA	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.0833
p.T135N	DO41235	UCEC	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.0833
p.N157I	TCGA-AB-2808	LAML	TCGA	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1389
p.N157I	DO21487	LAML	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1389
p.P147S	TCGA-EB-A5UL	SKCM	TCGA	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.6752
p.P147S	DO47601	SKCM	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.6752
p.T141I	TCGA-GN-A266	SKCM	TCGA	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.25
p.T141I	DO37432	SKCM	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.25
p.I151M	TCGA-IQ-A61E	HNSC	TCGA	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.3056
p.I151M	DO44429	HNSC	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.3056
p.E145D	TCGA-MV-A51V	BLCA	TCGA	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.5647
p.E145D	DO474	BLCA	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.5647
p.T146S	DO48757	LIRI	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.7116
p.P149S	DO222731	MELA	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.5641
p.K148N	DO229216	THCA	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.5806
p.Q148L	EW-7	bone	COSMIC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.7765
p.P145L	HA7-RCC	kidney	COSMIC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.7582
p.L135P	RS4-11	haematopoietic and lymphoid tissue	COSMIC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.0833
p.P145T	NCI-H2347	lung	COSMIC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.7031

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PSG11

UniProt ID: Q9UQ72

Entrez ID: 5680

Protein name: Pregnancy-specific beta-1-glycoprotein 11 (PS-beta-G-11) (PSBG-11) (Pregnancy-specific glycoprotein 11) (Pregnancy-specific beta-1-glycoprotein 13) (PS-beta-G-13) (PSBG-13) (Pregnancy-specific glycoprotein 13)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PSG11 in