DegronMD

Uniprot ID: Q9UQ72

Source protein: Pregnancy-specific beta-1-glycoprotein 11

Source gene: PSG11

Class: DEG_SCF_FBW7_1

Location: 144:150

E3 ligase: FBXW7

DEGRON score: 0.6282

ASA_SCORE: 64.2714

COIL: 0.7126

CONS_SCORE: 0.4792

DSS_SCORE: 0.2637

HELIX: 0.0329

FCONS_SCORE: 1.0967

RIG_SCORE: 0.7942

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L144M	TCGA-05-4427	LUAD	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.5999
p.L144M	DO23666	LUAD	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.5999
p.T146I	TCGA-44-7662	LUAD	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.7078
p.T146I	DO23597	LUAD	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.7078
p.S152Y	TCGA-49-4505	LUAD	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.2778
p.S152Y	DO25498	LUAD	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.2778
p.P158A	TCGA-61-2113	OV	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.1111
p.P158A	DO29328	OV	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.1111
p.R159M	TCGA-73-4658	LUAD	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.0833
p.R159M	DO23663	LUAD	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.0833
p.E145Q	TCGA-76-4934	GBM	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.5633
p.E145Q	DO12286	GBM	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.5633
p.P147H	TCGA-A5-A0G2	UCEC	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.7694
p.P147H	DO41235	UCEC	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.7694
p.T135N	TCGA-A5-A0G2	UCEC	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.0833
p.T135N	DO41235	UCEC	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.0833
p.N157I	TCGA-AB-2808	LAML	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.1389
p.N157I	DO21487	LAML	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.1389
p.P147S	TCGA-EB-A5UL	SKCM	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.6752
p.P147S	DO47601	SKCM	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.6752
p.T141I	TCGA-GN-A266	SKCM	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.25
p.T141I	DO37432	SKCM	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.25
p.I151M	TCGA-IQ-A61E	HNSC	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.3056
p.I151M	DO44429	HNSC	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.3056
p.E145D	TCGA-MV-A51V	BLCA	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.5647
p.E145D	DO474	BLCA	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.5647
p.T146S	DO48757	LIRI	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.7116
p.P149S	DO222731	MELA	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.5641
p.K148N	DO229216	THCA	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.5806
p.Q148L	EW-7	bone	COSMIC	LETPKPS	DEG_SCF_FBW7_1	0.7765
p.P145L	HA7-RCC	kidney	COSMIC	LETPKPS	DEG_SCF_FBW7_1	0.7582
p.L135P	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	LETPKPS	DEG_SCF_FBW7_1	0.0833
p.P145T	NCI-H2347	lung	COSMIC	LETPKPS	DEG_SCF_FBW7_1	0.7031

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LETPKPS

Degron related mutations and impact score

Drug responses associated with PSG11 mutations

All proteins holding degron of LETPKPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11464	Pregnancy-specific beta-1-glycoprotein 1	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.9956	More...
Q00888	Pregnancy-specific beta-1-glycoprotein 4	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.883	More...
Q9UQ72	Pregnancy-specific beta-1-glycoprotein 11	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.6282	More...
P11465	Pregnancy-specific beta-1-glycoprotein 2	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.8749	More...
Q13046	Putative pregnancy-specific beta-1-glycoprotein 7	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.9986	More...
Q16557	Pregnancy-specific beta-1-glycoprotein 3	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.9941	More...
Q9UQ74	Pregnancy-specific beta-1-glycoprotein 8	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.9298	More...