DegronMD - Q16557(PSG3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E145G	TCGA-AB-2808	LAML	TCGA	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.6087
p.E145G	TCGA-AB-2808	LAML	TCGA	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation altering degron motif	0.7199
p.E145G	DO21487	LAML	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.6087
p.E145G	DO21487	LAML	ICGC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation altering degron motif	0.7199
p.E160D	TCGA-AX-A2HA	UCEC	TCGA	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.0556
p.E160D	TCGA-MI-A75G	LIHC	TCGA	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.0556
p.E160D	DO49709	LIHC	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.0556
p.E160D	DO42504	UCEC	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.0556
p.S153G	TCGA-DU-5870	LGG	TCGA	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.25
p.S153G	TCGA-DU-5870	LGG	TCGA	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.1111
p.S153G	DO22199	LGG	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.25
p.S153G	DO22199	LGG	ICGC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.1111
p.L144V	TCGA-EE-A181	SKCM	TCGA	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.5654
p.L144V	TCGA-EE-A181	SKCM	TCGA	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation altering degron motif	0.5654
p.L144V	DO37444	SKCM	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.5654
p.L144V	DO37444	SKCM	ICGC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation altering degron motif	0.5654
p.N155S	TCGA-HU-A4GT	STAD	TCGA	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1944
p.N155S	TCGA-HU-A4GT	STAD	TCGA	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.0556
p.N155S	DO48020	STAD	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1944
p.N155S	DO48020	STAD	ICGC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.0556
p.E160K	TCGA-W3-A824	SKCM	TCGA	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.0556
p.E160K	DO220886	MELA	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.0556
p.E160K	DO51271	SKCM	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.0556
p.E160K	SIDM00545	Melanoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.0556
p.E160K	ACH-000987	Skin Cancer	CCLE	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.0556
p.E160K	Mewo	skin	COSMIC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.0556
p.R132G	DO234373	ESAD	ICGC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.1111
p.S154R	DO228978	LICA	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.2222
p.S154R	DO228978	LICA	ICGC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.0833
p.H137R	DO229050	LICA	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1389
p.H137R	DO229050	LICA	ICGC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.25
p.E134V	DO229053	LICA	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.0556
p.E134V	DO229053	LICA	ICGC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.1667
p.RE159RK	DO220886	MELA	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0
p.E145K	DO222749	MELA	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.591
p.E145K	DO222749	MELA	ICGC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation altering degron motif	0.7022
p.L156V	SIDM02019	Colorectal Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1667
p.G133R	ACH-002396	Bone Cancer	CCLE	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.1389
p.G133R	Sarc9371	bone	COSMIC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PSG3

UniProt ID: Q16557

Entrez ID: 5671

Protein name: Pregnancy-specific beta-1-glycoprotein 3 (PS-beta-G-3) (PSBG-3) (Pregnancy-specific glycoprotein 3) (Carcinoembryonic antigen SG5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PSG3 in