DegronMD

Uniprot ID: Q16557

Source protein: Pregnancy-specific beta-1-glycoprotein 3

Source gene: PSG3

Class: LIG_APCC_ABBA_1

Location: 140:145

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8118

ASA_SCORE: 53.6167

COIL: 0.4533

CONS_SCORE: 0.3559

DSS_SCORE: 0.4022

HELIX: 0.0138

FCONS_SCORE: 1.1114

RIG_SCORE: 0.868

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E145G	TCGA-AB-2808	LAML	TCGA	FTLYLE	LIG_APCC_ABBA_1	0.7199
p.E145G	DO21487	LAML	ICGC	FTLYLE	LIG_APCC_ABBA_1	0.7199
p.S153G	TCGA-DU-5870	LGG	TCGA	FTLYLE	LIG_APCC_ABBA_1	0.1111
p.S153G	DO22199	LGG	ICGC	FTLYLE	LIG_APCC_ABBA_1	0.1111
p.L144V	TCGA-EE-A181	SKCM	TCGA	FTLYLE	LIG_APCC_ABBA_1	0.5654
p.L144V	DO37444	SKCM	ICGC	FTLYLE	LIG_APCC_ABBA_1	0.5654
p.N155S	TCGA-HU-A4GT	STAD	TCGA	FTLYLE	LIG_APCC_ABBA_1	0.0556
p.N155S	DO48020	STAD	ICGC	FTLYLE	LIG_APCC_ABBA_1	0.0556
p.R132G	DO234373	ESAD	ICGC	FTLYLE	LIG_APCC_ABBA_1	0.1111
p.S154R	DO228978	LICA	ICGC	FTLYLE	LIG_APCC_ABBA_1	0.0833
p.H137R	DO229050	LICA	ICGC	FTLYLE	LIG_APCC_ABBA_1	0.25
p.E134V	DO229053	LICA	ICGC	FTLYLE	LIG_APCC_ABBA_1	0.1667
p.E145K	DO222749	MELA	ICGC	FTLYLE	LIG_APCC_ABBA_1	0.7022
p.G133R	ACH-002396	Bone Cancer	CCLE	FTLYLE	LIG_APCC_ABBA_1	0.1389
p.G133R	Sarc9371	bone	COSMIC	FTLYLE	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13046	Putative pregnancy-specific beta-1-glycoprotein 7	LIG_APCC_ABBA_1	140:145	FTLYLE	APC,CDC20,FZR1	0.8137	More...
Q16557	Pregnancy-specific beta-1-glycoprotein 3	LIG_APCC_ABBA_1	140:145	FTLYLE	APC,CDC20,FZR1	0.8118	More...
Q9UQ74	Pregnancy-specific beta-1-glycoprotein 8	LIG_APCC_ABBA_1	140:145	FTLYLE	APC,CDC20,FZR1	0.7537	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons