DegronMD

Uniprot ID: Q9UQ74

Source protein: Pregnancy-specific beta-1-glycoprotein 8

Source gene: PSG8

Class: LIG_APCC_ABBA_1

Location: 140:145

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7537

ASA_SCORE: 53.15

COIL: 0.418

CONS_SCORE: 0.447

DSS_SCORE: 0.3273

HELIX: 0.0175

FCONS_SCORE: 0.9671

RIG_SCORE: 0.8679

Show entries

Search:

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P144L	DO42312	UCEC	ICGC	FTLYLE	LIG_APCC_ABBA_1	0.7582
p.P144S	DO9876	COAD	ICGC	FTLYLE	LIG_APCC_ABBA_1	0.6752
p.P144S	DO24920	LUAD	ICGC	FTLYLE	LIG_APCC_ABBA_1	0.6752
p.P144S	DO222662	MELA	ICGC	FTLYLE	LIG_APCC_ABBA_1	0.6752
p.P144S	DO229459	SKCA	ICGC	FTLYLE	LIG_APCC_ABBA_1	0.6752
p.P144S	DO37659	SKCM	ICGC	FTLYLE	LIG_APCC_ABBA_1	0.6752
p.P144S	DO47395	SKCM	ICGC	FTLYLE	LIG_APCC_ABBA_1	0.6752
p.T141I	ACH-001853	Bile Duct Cancer	CCLE	FTLYLE	LIG_APCC_ABBA_1	0.5966
p.T139P	SIDM00683	Prostate Carcinoma	GDSC	FTLYLE	LIG_APCC_ABBA_1	0.3056
p.T139N	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	FTLYLE	LIG_APCC_ABBA_1	0.3056
p.T139N	ACH-000945	Lung Cancer	CCLE	FTLYLE	LIG_APCC_ABBA_1	0.3056
p.T139N	NCI-H650	lung	COSMIC	FTLYLE	LIG_APCC_ABBA_1	0.3056
p.H137N	SIDM00477	Esophageal Carcinoma	GDSC	FTLYLE	LIG_APCC_ABBA_1	0.25
p.H137N	OE33	oesophagus	COSMIC	FTLYLE	LIG_APCC_ABBA_1	0.25
p.G136A	TCGA-50-6592	LUAD	TCGA	FTLYLE	LIG_APCC_ABBA_1	0.2222
p.G136A	DO23742	LUAD	ICGC	FTLYLE	LIG_APCC_ABBA_1	0.2222
p.G136R	TCGA-D3-A8GQ	SKCM	TCGA	FTLYLE	LIG_APCC_ABBA_1	0.2222
p.G136R	TCGA-SR-A6MX	PCPG	TCGA	FTLYLE	LIG_APCC_ABBA_1	0.2222
p.G136R	DO51246	SKCM	ICGC	FTLYLE	LIG_APCC_ABBA_1	0.2222
p.T135P	SIDM01577	Plasma Cell Myeloma	GDSC	FTLYLE	LIG_APCC_ABBA_1	0.1944
p.T135P	ACH-000889	Myeloma	CCLE	FTLYLE	LIG_APCC_ABBA_1	0.1944
p.I151M	DO49003	CESC	ICGC	FTLYLE	LIG_APCC_ABBA_1	0.1667
p.K155N	DO228945	LICA	ICGC	FTLYLE	LIG_APCC_ABBA_1	0.1667
p.V134L	DO232224	PBCA	ICGC	FTLYLE	LIG_APCC_ABBA_1	0.1667
p.N155I	SK-MEL-28	skin	COSMIC	FTLYLE	LIG_APCC_ABBA_1	0.1667

Showing 1 to 25 of 38 entries

Show entries

Search:

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
No data available in table

Showing 0 to 0 of 0 entries

Show entries

Search:

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q16557	Pregnancy-specific beta-1-glycoprotein 3	LIG_APCC_ABBA_1	140:145	FTLYLE	APC,CDC20,FZR1	0.8118	More...
Q9UQ74	Pregnancy-specific beta-1-glycoprotein 8	LIG_APCC_ABBA_1	140:145	FTLYLE	APC,CDC20,FZR1	0.7537	More...
Q13046	Putative pregnancy-specific beta-1-glycoprotein 7	LIG_APCC_ABBA_1	140:145	FTLYLE	APC,CDC20,FZR1	0.8137	More...

Showing 1 to 3 of 3 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons