DegronMD

Uniprot ID: Q9UQ74

Source protein: Pregnancy-specific beta-1-glycoprotein 8

Source gene: PSG8

Class: LIG_APCC_ABBA_1

Location: 140:145

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7537

ASA_SCORE: 53.15

COIL: 0.418

CONS_SCORE: 0.447

DSS_SCORE: 0.3273

HELIX: 0.0175

FCONS_SCORE: 0.9671

RIG_SCORE: 0.8679

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G136A	TCGA-50-6592	LUAD	TCGA	FTLYLE	LIG_APCC_ABBA_1	0.2222
p.G136A	DO23742	LUAD	ICGC	FTLYLE	LIG_APCC_ABBA_1	0.2222
p.E130D	TCGA-AC-A2B8	BRCA	TCGA	FTLYLE	LIG_APCC_ABBA_1	0.0556
p.E130D	DO5884	BRCA	ICGC	FTLYLE	LIG_APCC_ABBA_1	0.0556
p.E130D	DO233652	GACA	ICGC	FTLYLE	LIG_APCC_ABBA_1	0.0556
p.G133A	TCGA-AN-A0XW	BRCA	TCGA	FTLYLE	LIG_APCC_ABBA_1	0.1389
p.G133A	DO1873	BRCA	ICGC	FTLYLE	LIG_APCC_ABBA_1	0.1389
p.N131T	TCGA-AZ-6598	COAD	TCGA	FTLYLE	LIG_APCC_ABBA_1	0.0833
p.N131T	DO10276	COAD	ICGC	FTLYLE	LIG_APCC_ABBA_1	0.0833
p.E130G	TCGA-AZ-6598	COAD	TCGA	FTLYLE	LIG_APCC_ABBA_1	0.0556
p.E130G	DO10276	COAD	ICGC	FTLYLE	LIG_APCC_ABBA_1	0.0556
p.G136R	TCGA-D3-A8GQ	SKCM	TCGA	FTLYLE	LIG_APCC_ABBA_1	0.2222
p.G136R	TCGA-SR-A6MX	PCPG	TCGA	FTLYLE	LIG_APCC_ABBA_1	0.2222
p.G136R	DO51246	SKCM	ICGC	FTLYLE	LIG_APCC_ABBA_1	0.2222
p.I151M	DO49003	CESC	ICGC	FTLYLE	LIG_APCC_ABBA_1	0.1667
p.P144S	DO9876	COAD	ICGC	FTLYLE	LIG_APCC_ABBA_1	0.6752
p.P144S	DO24920	LUAD	ICGC	FTLYLE	LIG_APCC_ABBA_1	0.6752
p.P144S	DO222662	MELA	ICGC	FTLYLE	LIG_APCC_ABBA_1	0.6752
p.P144S	DO229459	SKCA	ICGC	FTLYLE	LIG_APCC_ABBA_1	0.6752
p.P144S	DO37659	SKCM	ICGC	FTLYLE	LIG_APCC_ABBA_1	0.6752
p.P144S	DO47395	SKCM	ICGC	FTLYLE	LIG_APCC_ABBA_1	0.6752
p.K155N	DO228945	LICA	ICGC	FTLYLE	LIG_APCC_ABBA_1	0.1667
p.V134L	DO232224	PBCA	ICGC	FTLYLE	LIG_APCC_ABBA_1	0.1667
p.P144L	DO42312	UCEC	ICGC	FTLYLE	LIG_APCC_ABBA_1	0.7582
p.T139P	SIDM00683	Prostate Carcinoma	GDSC	FTLYLE	LIG_APCC_ABBA_1	0.3056
p.H137N	SIDM00477	Esophageal Carcinoma	GDSC	FTLYLE	LIG_APCC_ABBA_1	0.25
p.H137N	OE33	oesophagus	COSMIC	FTLYLE	LIG_APCC_ABBA_1	0.25
p.S153G	SIDM00333	Endometrial Carcinoma	GDSC	FTLYLE	LIG_APCC_ABBA_1	0.1111
p.S153G	ACH-000988	Endometrial/Uterine Cancer	CCLE	FTLYLE	LIG_APCC_ABBA_1	0.1111
p.S153G	MFE-319	endometrium	COSMIC	FTLYLE	LIG_APCC_ABBA_1	0.1111
p.T139N	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	FTLYLE	LIG_APCC_ABBA_1	0.3056
p.T139N	ACH-000945	Lung Cancer	CCLE	FTLYLE	LIG_APCC_ABBA_1	0.3056
p.T139N	NCI-H650	lung	COSMIC	FTLYLE	LIG_APCC_ABBA_1	0.3056
p.T135P	SIDM01577	Plasma Cell Myeloma	GDSC	FTLYLE	LIG_APCC_ABBA_1	0.1944
p.T135P	ACH-000889	Myeloma	CCLE	FTLYLE	LIG_APCC_ABBA_1	0.1944
p.G133E	ACH-001563	Skin Cancer	CCLE	FTLYLE	LIG_APCC_ABBA_1	0.1389
p.T141I	ACH-001853	Bile Duct Cancer	CCLE	FTLYLE	LIG_APCC_ABBA_1	0.5966
p.N155I	SK-MEL-28	skin	COSMIC	FTLYLE	LIG_APCC_ABBA_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FTLYLE

Degron related mutations and impact score

Drug responses associated with PSG8 mutations

All proteins holding degron of FTLYLE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13046	Putative pregnancy-specific beta-1-glycoprotein 7	LIG_APCC_ABBA_1	140:145	FTLYLE	APC,CDC20,FZR1	0.8137	More...
Q16557	Pregnancy-specific beta-1-glycoprotein 3	LIG_APCC_ABBA_1	140:145	FTLYLE	APC,CDC20,FZR1	0.8118	More...
Q9UQ74	Pregnancy-specific beta-1-glycoprotein 8	LIG_APCC_ABBA_1	140:145	FTLYLE	APC,CDC20,FZR1	0.7537	More...