DegronMD

Uniprot ID: Q13046

Source protein: Putative pregnancy-specific beta-1-glycoprotein 7

Source gene: PSG7

Class: LIG_APCC_ABBA_1

Location: 140:145

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8137

ASA_SCORE: 66.3667

COIL: 0.533

CONS_SCORE: 0.216

DSS_SCORE: 0.3361

HELIX: 0.0572

FCONS_SCORE: 0.677

RIG_SCORE: 0.8946

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G132R	TCGA-AA-3947	COAD	TCGA	FTLYLE	LIG_APCC_ABBA_1	0.1111
p.E145D	TCGA-AO-A03M	BRCA	TCGA	FTLYLE	LIG_APCC_ABBA_1	0.5647
p.G130R	TCGA-EE-A3JD	SKCM	TCGA	FTLYLE	LIG_APCC_ABBA_1	0.0556
p.R137H	TCGA-S9-A6U0	LGG	TCGA	FTLYLE	LIG_APCC_ABBA_1	0.25
p.T137I	SIDM00973	Melanoma	GDSC	FTLYLE	LIG_APCC_ABBA_1	0.25
p.T137I	SIDM01171	Glioblastoma	GDSC	FTLYLE	LIG_APCC_ABBA_1	0.25
p.T137I	SIDM01067	Non-Small Cell Lung Carcinoma	GDSC	FTLYLE	LIG_APCC_ABBA_1	0.25
p.T137I	SIDM01775	B-Cell Non-Hodgkin's Lymphoma	GDSC	FTLYLE	LIG_APCC_ABBA_1	0.25
p.N132K	SIDM01059	Melanoma	GDSC	FTLYLE	LIG_APCC_ABBA_1	0.1111
p.N132K	IPC-298	skin	COSMIC	FTLYLE	LIG_APCC_ABBA_1	0.1111
p.N155I	WIL2-NS	haematopoietic_and_lymphoid_tissue	COSMIC	FTLYLE	LIG_APCC_ABBA_1	0.0556
p.T141S	CL-11	large_intestine	COSMIC	FTLYLE	LIG_APCC_ABBA_1	0.6005
p.L142I	RCC-JF	kidney	COSMIC	FTLYLE	LIG_APCC_ABBA_1	0.6063

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13046	Putative pregnancy-specific beta-1-glycoprotein 7	LIG_APCC_ABBA_1	140:145	FTLYLE	APC,CDC20,FZR1	0.8137	More...
Q16557	Pregnancy-specific beta-1-glycoprotein 3	LIG_APCC_ABBA_1	140:145	FTLYLE	APC,CDC20,FZR1	0.8118	More...
Q9UQ74	Pregnancy-specific beta-1-glycoprotein 8	LIG_APCC_ABBA_1	140:145	FTLYLE	APC,CDC20,FZR1	0.7537	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons