DegronMD - Q9UQ74(PSG8)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G136A	TCGA-50-6592	LUAD	TCGA	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1111
p.G136A	TCGA-50-6592	LUAD	TCGA	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.2222
p.G136A	DO23742	LUAD	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1111
p.G136A	DO23742	LUAD	ICGC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.2222
p.P149L	TCGA-55-7727	LUAD	TCGA	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.6471
p.P158T	TCGA-77-A5G8	LUSC	TCGA	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1111
p.E130D	TCGA-AC-A2B8	BRCA	TCGA	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.0556
p.E130D	DO5884	BRCA	ICGC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.0556
p.E130D	DO233652	GACA	ICGC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.0556
p.G133A	TCGA-AN-A0XW	BRCA	TCGA	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.1389
p.G133A	DO1873	BRCA	ICGC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.1389
p.N131T	TCGA-AZ-6598	COAD	TCGA	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.0833
p.N131T	DO10276	COAD	ICGC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.0833
p.E130G	TCGA-AZ-6598	COAD	TCGA	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.0556
p.E130G	DO10276	COAD	ICGC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.0556
p.R159M	TCGA-CN-A63W	HNSC	TCGA	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.0833
p.R159M	DO49031	HNSC	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.0833
p.G136R	TCGA-D3-A8GQ	SKCM	TCGA	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1111
p.G136R	TCGA-D3-A8GQ	SKCM	TCGA	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.2222
p.G136R	TCGA-SR-A6MX	PCPG	TCGA	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1111
p.G136R	TCGA-SR-A6MX	PCPG	TCGA	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.2222
p.G136R	DO51246	SKCM	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1111
p.G136R	DO51246	SKCM	ICGC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.2222
p.K157N	DO227871	BRCA	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1389
p.K157N	DO229073	PRAD	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1389
p.I151M	DO49003	CESC	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.3056
p.I151M	DO49003	CESC	ICGC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.1667
p.P144S	DO9876	COAD	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.6752
p.P144S	DO9876	COAD	ICGC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation altering degron motif	0.6752
p.P144S	DO24920	LUAD	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.6752
p.P144S	DO24920	LUAD	ICGC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation altering degron motif	0.6752
p.P144S	DO222662	MELA	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.6752
p.P144S	DO222662	MELA	ICGC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation altering degron motif	0.6752
p.P144S	DO229459	SKCA	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.6752
p.P144S	DO229459	SKCA	ICGC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation altering degron motif	0.6752
p.P144S	DO37659	SKCM	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.6752
p.P144S	DO37659	SKCM	ICGC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation altering degron motif	0.6752
p.P144S	DO47395	SKCM	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.6752
p.P144S	DO47395	SKCM	ICGC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation altering degron motif	0.6752
p.K155N	DO228945	LICA	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation substituting flanking lysine	0.3056
p.K155N	DO228945	LICA	ICGC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation substituting flanking lysine	0.1667
p.P158H	DO228978	LICA	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1111
p.V134L	DO232224	PBCA	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.0556
p.V134L	DO232224	PBCA	ICGC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.1667
p.E160K	DO50284	SKCM	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.0556
p.E160K	DO219481	SKCM	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.0556
p.P144L	DO42312	UCEC	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.7582
p.P144L	DO42312	UCEC	ICGC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation altering degron motif	0.7582
p.T139P	SIDM00683	Prostate Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1944
p.T139P	SIDM00683	Prostate Carcinoma	GDSC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.3056
p.H137N	SIDM00477	Esophageal Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1389
p.H137N	SIDM00477	Esophageal Carcinoma	GDSC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.25
p.H137N	OE33	oesophagus	COSMIC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1389
p.H137N	OE33	oesophagus	COSMIC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.25
p.S153G	SIDM00333	Endometrial Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.25
p.S153G	SIDM00333	Endometrial Carcinoma	GDSC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.1111
p.S153G	ACH-000988	Endometrial/Uterine Cancer	CCLE	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.25
p.S153G	ACH-000988	Endometrial/Uterine Cancer	CCLE	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.1111
p.S153G	MFE-319	endometrium	COSMIC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.25
p.S153G	MFE-319	endometrium	COSMIC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.1111
p.T139N	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1944
p.T139N	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.3056
p.T139N	ACH-000945	Lung Cancer	CCLE	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1944
p.T139N	ACH-000945	Lung Cancer	CCLE	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.3056
p.T139N	NCI-H650	lung	COSMIC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1944
p.T139N	NCI-H650	lung	COSMIC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.3056
p.T135P	SIDM01577	Plasma Cell Myeloma	GDSC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.0833
p.T135P	SIDM01577	Plasma Cell Myeloma	GDSC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.1944
p.T135P	ACH-000889	Myeloma	CCLE	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.0833
p.T135P	ACH-000889	Myeloma	CCLE	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.1944
p.G133E	ACH-001563	Skin Cancer	CCLE	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.1389
p.T141I	ACH-001853	Bile Duct Cancer	CCLE	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation altering degron motif	0.5966
p.N155I	SK-MEL-28	skin	COSMIC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation substituting flanking lysine	0.3056
p.N155I	SK-MEL-28	skin	COSMIC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation substituting flanking lysine	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PSG8

UniProt ID: Q9UQ74

Entrez ID: 440533

Protein name: Pregnancy-specific beta-1-glycoprotein 8 (PS-beta-G-8) (PSBG-8) (Pregnancy-specific glycoprotein 8)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PSG8 in