DegronMD

Uniprot ID: Q9UQ74

Source protein: Pregnancy-specific beta-1-glycoprotein 8

Source gene: PSG8

Class: DEG_SCF_FBW7_1

Location: 144:150

E3 ligase: FBXW7

DEGRON score: 0.9298

ASA_SCORE: 74.7571

COIL: 0.766

CONS_SCORE: 0.4492

DSS_SCORE: 0.3276

HELIX: 0.0166

FCONS_SCORE: 0.9537

RIG_SCORE: 0.7628

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G136A	TCGA-50-6592	LUAD	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.1111
p.G136A	DO23742	LUAD	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.1111
p.P149L	TCGA-55-7727	LUAD	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.6471
p.P158T	TCGA-77-A5G8	LUSC	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.1111
p.R159M	TCGA-CN-A63W	HNSC	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.0833
p.R159M	DO49031	HNSC	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.0833
p.G136R	TCGA-D3-A8GQ	SKCM	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.1111
p.G136R	TCGA-SR-A6MX	PCPG	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.1111
p.G136R	DO51246	SKCM	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.1111
p.K157N	DO227871	BRCA	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.1389
p.K157N	DO229073	PRAD	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.1389
p.I151M	DO49003	CESC	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.3056
p.P144S	DO9876	COAD	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.6752
p.P144S	DO24920	LUAD	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.6752
p.P144S	DO222662	MELA	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.6752
p.P144S	DO229459	SKCA	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.6752
p.P144S	DO37659	SKCM	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.6752
p.P144S	DO47395	SKCM	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.6752
p.K155N	DO228945	LICA	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.3056
p.P158H	DO228978	LICA	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.1111
p.V134L	DO232224	PBCA	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.0556
p.E160K	DO50284	SKCM	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.0556
p.E160K	DO219481	SKCM	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.0556
p.P144L	DO42312	UCEC	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.7582
p.T139P	SIDM00683	Prostate Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.1944
p.H137N	SIDM00477	Esophageal Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.1389
p.H137N	OE33	oesophagus	COSMIC	LETPKPS	DEG_SCF_FBW7_1	0.1389
p.S153G	SIDM00333	Endometrial Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.25
p.S153G	ACH-000988	Endometrial/Uterine Cancer	CCLE	LETPKPS	DEG_SCF_FBW7_1	0.25
p.S153G	MFE-319	endometrium	COSMIC	LETPKPS	DEG_SCF_FBW7_1	0.25
p.T139N	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.1944
p.T139N	ACH-000945	Lung Cancer	CCLE	LETPKPS	DEG_SCF_FBW7_1	0.1944
p.T139N	NCI-H650	lung	COSMIC	LETPKPS	DEG_SCF_FBW7_1	0.1944
p.T135P	SIDM01577	Plasma Cell Myeloma	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.0833
p.T135P	ACH-000889	Myeloma	CCLE	LETPKPS	DEG_SCF_FBW7_1	0.0833
p.N155I	SK-MEL-28	skin	COSMIC	LETPKPS	DEG_SCF_FBW7_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LETPKPS

Degron related mutations and impact score

Drug responses associated with PSG8 mutations

All proteins holding degron of LETPKPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11464	Pregnancy-specific beta-1-glycoprotein 1	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.9956	More...
Q00888	Pregnancy-specific beta-1-glycoprotein 4	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.883	More...
Q9UQ72	Pregnancy-specific beta-1-glycoprotein 11	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.6282	More...
P11465	Pregnancy-specific beta-1-glycoprotein 2	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.8749	More...
Q13046	Putative pregnancy-specific beta-1-glycoprotein 7	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.9986	More...
Q16557	Pregnancy-specific beta-1-glycoprotein 3	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.9941	More...
Q9UQ74	Pregnancy-specific beta-1-glycoprotein 8	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.9298	More...