DegronMD

Uniprot ID: P11464

Source protein: Pregnancy-specific beta-1-glycoprotein 1

Source gene: PSG1

Class: DEG_SCF_FBW7_1

Location: 144:150

E3 ligase: FBXW7

DEGRON score: 0.9956

ASA_SCORE: 77.6143

COIL: 0.821

CONS_SCORE: 0.4067

DSS_SCORE: 0.4512

HELIX: 0.0271

FCONS_SCORE: 0.8408

RIG_SCORE: 0.7295

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E160D	TCGA-55-8506	LUAD	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.0556
p.E160D	DO45390	LUAD	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.0556
p.P158L	TCGA-90-A4ED	LUSC	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.1111
p.P158L	DO45482	LUSC	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.1111
p.P158S	TCGA-90-A4ED	LUSC	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.1111
p.P158S	DO45482	LUSC	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.1111
p.P158S	DO220910	MELA	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.1111
p.P158S	SIDM00596	Endometrial Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.1111
p.P158S	ACH-000941	Endometrial/Uterine Cancer	CCLE	LETPKPS	DEG_SCF_FBW7_1	0.1111
p.P158S	ACH-000954	Endometrial/Uterine Cancer	CCLE	LETPKPS	DEG_SCF_FBW7_1	0.1111
p.P158S	ACH-001517	Endometrial/Uterine Cancer	CCLE	LETPKPS	DEG_SCF_FBW7_1	0.1111
p.P158S	HEC-1	endometrium	COSMIC	LETPKPS	DEG_SCF_FBW7_1	0.1111
p.E145G	TCGA-D9-A6EC	SKCM	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.6087
p.E145G	DO50291	SKCM	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.6087
p.E145D	TCGA-FD-A3SR	BLCA	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.5647
p.E145D	DO810	BLCA	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.5647
p.E160K	TCGA-FW-A3R5	SKCM	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.0556
p.E160K	DO229479	SKCA	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.0556
p.E160K	DO37406	SKCM	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.0556
p.S150F	TCGA-QC-A7B5	SARC	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.7982
p.S150F	DO220239	SARC	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.7982
p.S154N	TCGA-VQ-A94U	STAD	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.2222
p.S154N	DO222378	STAD	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.2222
p.R137P	DO225002	BRCA	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.1389
p.R137P	SIDM00557	Neuroblastoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.1389
p.R137P	KP-N-RT-BM-1	autonomic_ganglia	COSMIC	LETPKPS	DEG_SCF_FBW7_1	0.1389
p.K148R	DO233206	GACA	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.6126
p.R137S	DO229018	LICA	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.1389
p.T139I	DO27847	MALY	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.1944
p.N155T	DO32980	PACA	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.1944
p.K148T	DO49445	PACA	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.6195
p.P158H	SIDM00939	Non-Small Cell Lung Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.1111
p.P158H	ACH-000826	Lung Cancer	CCLE	LETPKPS	DEG_SCF_FBW7_1	0.1111
p.P158H	CAL-12T	lung	COSMIC	LETPKPS	DEG_SCF_FBW7_1	0.1111
p.P147S	SIDM00711	Squamous Cell Lung Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.6752
p.P147S	ACH-000727	Lung Cancer	CCLE	LETPKPS	DEG_SCF_FBW7_1	0.6752
p.P147S	NCI-H2066	lung	COSMIC	LETPKPS	DEG_SCF_FBW7_1	0.6752
p.T135A	SIDM00711	Squamous Cell Lung Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.0833
p.T135A	ACH-000727	Lung Cancer	CCLE	LETPKPS	DEG_SCF_FBW7_1	0.0833
p.T135A	NCI-H2066	lung	COSMIC	LETPKPS	DEG_SCF_FBW7_1	0.0833
p.L156V	SIDM01158	Squamous Cell Lung Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.1667
p.L156V	ACH-000669	Lung Cancer	CCLE	LETPKPS	DEG_SCF_FBW7_1	0.1667
p.L156V	SW900	lung	COSMIC	LETPKPS	DEG_SCF_FBW7_1	0.1667
p.P149T	ACH-000870	Lung Cancer	CCLE	LETPKPS	DEG_SCF_FBW7_1	0.5919
p.P149S	ACH-002508	Skin Cancer	CCLE	LETPKPS	DEG_SCF_FBW7_1	0.5641

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LETPKPS

Degron related mutations and impact score

Drug responses associated with PSG1 mutations

All proteins holding degron of LETPKPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11464	Pregnancy-specific beta-1-glycoprotein 1	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.9956	More...
Q00888	Pregnancy-specific beta-1-glycoprotein 4	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.883	More...
Q9UQ72	Pregnancy-specific beta-1-glycoprotein 11	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.6282	More...
P11465	Pregnancy-specific beta-1-glycoprotein 2	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.8749	More...
Q13046	Putative pregnancy-specific beta-1-glycoprotein 7	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.9986	More...
Q16557	Pregnancy-specific beta-1-glycoprotein 3	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.9941	More...
Q9UQ74	Pregnancy-specific beta-1-glycoprotein 8	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.9298	More...