DegronMD

Uniprot ID: Q00888

Source protein: Pregnancy-specific beta-1-glycoprotein 4

Source gene: PSG4

Class: DEG_SCF_FBW7_1

Location: 144:150

E3 ligase: FBXW7

DEGRON score: 0.883

ASA_SCORE: 70.3714

COIL: 0.7647

CONS_SCORE: 0.5197

DSS_SCORE: 0.4178

HELIX: 0.0281

FCONS_SCORE: 1.3247

RIG_SCORE: 0.7372

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T146S	TCGA-06-0145	GBM	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.7116
p.T146S	DO13192	GBM	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.7116
p.P158L	TCGA-FR-A3YN	SKCM	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.1111
p.P158L	DO38111	SKCM	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.1111
p.G136E	TCGA-FS-A1ZW	SKCM	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.1111
p.G136E	DO37519	SKCM	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.1111
p.S152F	TCGA-OD-A75X	SKCM	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.2778
p.S152F	DO229459	SKCA	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.2778
p.S152F	DO229462	SKCA	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.2778
p.S152F	DO48601	SKCM	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.2778
p.E160Q	DO3221	BRCA	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.0556
p.K145Q	DO8264	COAD	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.6944
p.S147P	DO229010	COCA	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.6752
p.S147P	DO229013	COCA	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.6752
p.S147P	DO229016	COCA	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.6752
p.S147P	DO229003	COCA	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.6752
p.S147P	DO229005	COCA	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.6752
p.S147P	DO234205	ESAD	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.6752
p.S147P	DO234285	ESAD	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.6752
p.V134I	DO233650	GACA	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.0556
p.T139N	DO228971	LICA	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.1944
p.H137Y	DO229052	LICA	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.1389
p.R159S	DO224563	LUSC	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.0833
p.L144P	DO220906	MELA	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.6471
p.L156V	DO222678	MELA	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.1667
p.L156V	DO37770	SKCM	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.1667
p.N155D	DO232445	PBCA	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.1944
p.I153T	DO42312	UCEC	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.25
p.E160D	DO41020	UCEC	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.0556
p.S147F	DO43755	UCEC	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.7982
p.S153R	SIDM00135	Breast Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.25
p.S153R	ACH-000148	Breast Cancer	CCLE	LETPKPS	DEG_SCF_FBW7_1	0.25
p.S153R	ACH-000532	Colon/Colorectal Cancer	CCLE	LETPKPS	DEG_SCF_FBW7_1	0.25
p.S153R	Hs-578-T	breast	COSMIC	LETPKPS	DEG_SCF_FBW7_1	0.25
p.P158S	SK-MES-1	lung	COSMIC	LETPKPS	DEG_SCF_FBW7_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LETPKPS

Degron related mutations and impact score

Drug responses associated with PSG4 mutations

All proteins holding degron of LETPKPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11464	Pregnancy-specific beta-1-glycoprotein 1	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.9956	More...
Q00888	Pregnancy-specific beta-1-glycoprotein 4	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.883	More...
Q9UQ72	Pregnancy-specific beta-1-glycoprotein 11	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.6282	More...
P11465	Pregnancy-specific beta-1-glycoprotein 2	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.8749	More...
Q13046	Putative pregnancy-specific beta-1-glycoprotein 7	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.9986	More...
Q16557	Pregnancy-specific beta-1-glycoprotein 3	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.9941	More...
Q9UQ74	Pregnancy-specific beta-1-glycoprotein 8	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.9298	More...