DegronMD

Uniprot ID: P11465

Source protein: Pregnancy-specific beta-1-glycoprotein 2

Source gene: PSG2

Class: DEG_SCF_FBW7_1

Location: 144:150

E3 ligase: FBXW7

DEGRON score: 0.8749

ASA_SCORE: 71.1429

COIL: 0.7599

CONS_SCORE: 0.6215

DSS_SCORE: 0.2774

HELIX: 0.036

FCONS_SCORE: 1.0982

RIG_SCORE: 0.793

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G136A	TCGA-17-Z026	LUAD	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.1111
p.S153I	TCGA-90-A59Q	LUSC	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.25
p.S153I	DO50103	LUSC	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.25
p.Y143H	TCGA-CR-7402	HNSC	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.3056
p.Y143H	DO15727	HNSC	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.3056
p.G136E	TCGA-EB-A41A	SKCM	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.1111
p.G136E	TCGA-EE-A2GE	SKCM	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.1111
p.G136E	DO37429	SKCM	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.1111
p.G136E	DO38016	SKCM	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.1111
p.E160K	TCGA-EE-A182	SKCM	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.0556
p.E160K	DO37814	SKCM	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.0556
p.E160K	SIDM00140	Melanoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.0556
p.E160K	ACH-000968	Skin Cancer	CCLE	LETPKPS	DEG_SCF_FBW7_1	0.0556
p.E160K	COLO-792	skin	COSMIC	LETPKPS	DEG_SCF_FBW7_1	0.0556
p.S153N	TCGA-EE-A29E	SKCM	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.25
p.S153N	DO37831	SKCM	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.25
p.S152F	TCGA-FR-A7U9	SKCM	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.2778
p.S152F	DO48546	SKCM	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.2778
p.P147R	DO228197	LICA	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.7512
p.F140L	DO229045	LICA	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.2222
p.E145V	DO229446	SKCA	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.6582
p.N155K	SIDM01199	Hepatocellular Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.1944
p.N155K	ACH-000493	Liver Cancer	CCLE	LETPKPS	DEG_SCF_FBW7_1	0.1944
p.N155K	SNU-423	liver	COSMIC	LETPKPS	DEG_SCF_FBW7_1	0.1944
p.Y137C	SIDM00855	Other Sarcomas	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.1389
p.Y137C	SIDM00846	Cervical Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.1389
p.Y137C	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.1389
p.Y137C	SIDM00694	Other Solid Cancers	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.1389
p.Y137C	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.1389
p.Y137C	SIDM00309	Mesothelioma	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.1389
p.Y137C	SIDM00721	Small Cell Lung Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.1389
p.Y137H	SIDM00855	Other Sarcomas	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.1389
p.Y137H	SIDM00846	Cervical Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.1389
p.Y137H	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.1389
p.Y137H	SIDM00694	Other Solid Cancers	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.1389
p.Y137H	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.1389
p.Y137H	SIDM00309	Mesothelioma	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.1389
p.Y137H	SIDM00721	Small Cell Lung Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.1389
p.V134L	SIDM01175	Other Sarcomas	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.0556
p.V134L	ACH-002309	Sarcoma	CCLE	LETPKPS	DEG_SCF_FBW7_1	0.0556
p.V134L	SW684	soft_tissue	COSMIC	LETPKPS	DEG_SCF_FBW7_1	0.0556
p.K148N	SIDM01045	Endometrial Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.5806
p.K148N	ACH-000978	Endometrial/Uterine Cancer	CCLE	LETPKPS	DEG_SCF_FBW7_1	0.5806
p.K148N	EN	endometrium	COSMIC	LETPKPS	DEG_SCF_FBW7_1	0.5806
p.L144P	SIDM00228	Thyroid Gland Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.6471

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LETPKPS

Degron related mutations and impact score

Drug responses associated with PSG2 mutations

All proteins holding degron of LETPKPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11464	Pregnancy-specific beta-1-glycoprotein 1	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.9956	More...
Q00888	Pregnancy-specific beta-1-glycoprotein 4	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.883	More...
Q9UQ72	Pregnancy-specific beta-1-glycoprotein 11	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.6282	More...
P11465	Pregnancy-specific beta-1-glycoprotein 2	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.8749	More...
Q13046	Putative pregnancy-specific beta-1-glycoprotein 7	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.9986	More...
Q16557	Pregnancy-specific beta-1-glycoprotein 3	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.9941	More...
Q9UQ74	Pregnancy-specific beta-1-glycoprotein 8	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.9298	More...