DegronMD - Q13046(PSG7)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G132R	TCGA-AA-3947	COAD	TCGA	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.1111
p.N157K	TCGA-AA-A02O	COAD	TCGA	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1389
p.E145D	TCGA-AO-A03M	BRCA	TCGA	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.5647
p.E145D	TCGA-AO-A03M	BRCA	TCGA	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation altering degron motif	0.5647
p.P147T	TCGA-CN-6011	HNSC	TCGA	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.7031
p.E160K	TCGA-D3-A8GB	SKCM	TCGA	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.0556
p.P149L	TCGA-EE-A3JA	SKCM	TCGA	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.6471
p.P149L	Sarc9371	bone	COSMIC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.6471
p.G130R	TCGA-EE-A3JD	SKCM	TCGA	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.0556
p.R137H	TCGA-S9-A6U0	LGG	TCGA	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1389
p.R137H	TCGA-S9-A6U0	LGG	TCGA	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.25
p.T137I	SIDM00973	Melanoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1389
p.T137I	SIDM00973	Melanoma	GDSC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.25
p.T137I	SIDM01171	Glioblastoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1389
p.T137I	SIDM01171	Glioblastoma	GDSC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.25
p.T137I	SIDM01067	Non-Small Cell Lung Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1389
p.T137I	SIDM01067	Non-Small Cell Lung Carcinoma	GDSC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.25
p.T137I	SIDM01775	B-Cell Non-Hodgkin's Lymphoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1389
p.T137I	SIDM01775	B-Cell Non-Hodgkin's Lymphoma	GDSC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.25
p.I150V	SIDM00969	Ovarian Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.7076
p.I150V	DOV13	ovary	COSMIC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.7076
p.Y147C	SIDM00969	Ovarian Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.7087
p.Y147C	SIDM00656	Burkitt's Lymphoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.7087
p.Y147C	SIDM00846	Cervical Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.7087
p.Y147C	SIDM01039	Other Solid Cancers	GDSC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.7087
p.Y147C	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.7087
p.Y147C	SIDM00844	Burkitt's Lymphoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.7087
p.Y147C	SIDM00431	T-Lymphoblastic Leukemia	GDSC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.7087
p.Y147C	SIDM00721	Small Cell Lung Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.7087
p.Y147C	SIDM00785	Acute Myeloid Leukemia	GDSC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.7087
p.Y147C	SIDM00641	Burkitt's Lymphoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.7087
p.N132K	SIDM01059	Melanoma	GDSC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.1111
p.N132K	IPC-298	skin	COSMIC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.1111
p.S150Y	NCI-H2172	lung	COSMIC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.712
p.N155I	WIL2-NS	haematopoietic and lymphoid tissue	COSMIC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1944
p.N155I	WIL2-NS	haematopoietic and lymphoid tissue	COSMIC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation rewiring degron network	0.0556
p.T141S	CL-11	large intestine	COSMIC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation altering degron motif	0.6005
p.L142I	RCC-JF	kidney	COSMIC	FTLYLE	LIG_APCC_ABBA_1	140:145	Mutation altering degron motif	0.6063

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PSG7

UniProt ID: Q13046

Entrez ID: 5676

Protein name: Putative pregnancy-specific beta-1-glycoprotein 7 (PS-beta-G-7) (PSBG-7) (Pregnancy-specific glycoprotein 7)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PSG7 in