DegronMD

Uniprot ID: Q13046

Source protein: Putative pregnancy-specific beta-1-glycoprotein 7

Source gene: PSG7

Class: DEG_SCF_FBW7_1

Location: 144:150

E3 ligase: FBXW7

DEGRON score: 0.9986

ASA_SCORE: 77.0286

COIL: 0.7999

CONS_SCORE: 0.2206

DSS_SCORE: 0.3298

HELIX: 0.0213

FCONS_SCORE: 0.6597

RIG_SCORE: 0.781

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N157K	TCGA-AA-A02O	COAD	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.1389
p.E145D	TCGA-AO-A03M	BRCA	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.5647
p.P147T	TCGA-CN-6011	HNSC	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.7031
p.E160K	TCGA-D3-A8GB	SKCM	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.0556
p.P149L	TCGA-EE-A3JA	SKCM	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.6471
p.P149L	Sarc9371	bone	COSMIC	LETPKPS	DEG_SCF_FBW7_1	0.6471
p.R137H	TCGA-S9-A6U0	LGG	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.1389
p.T137I	SIDM00973	Melanoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.1389
p.T137I	SIDM01171	Glioblastoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.1389
p.T137I	SIDM01067	Non-Small Cell Lung Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.1389
p.T137I	SIDM01775	B-Cell Non-Hodgkin's Lymphoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.1389
p.I150V	SIDM00969	Ovarian Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.7076
p.I150V	DOV13	ovary	COSMIC	LETPKPS	DEG_SCF_FBW7_1	0.7076
p.Y147C	SIDM00969	Ovarian Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.7087
p.Y147C	SIDM00656	Burkitt's Lymphoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.7087
p.Y147C	SIDM00846	Cervical Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.7087
p.Y147C	SIDM01039	Other Solid Cancers	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.7087
p.Y147C	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.7087
p.Y147C	SIDM00844	Burkitt's Lymphoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.7087
p.Y147C	SIDM00431	T-Lymphoblastic Leukemia	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.7087
p.Y147C	SIDM00721	Small Cell Lung Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.7087
p.Y147C	SIDM00785	Acute Myeloid Leukemia	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.7087
p.Y147C	SIDM00641	Burkitt's Lymphoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.7087
p.S150Y	NCI-H2172	lung	COSMIC	LETPKPS	DEG_SCF_FBW7_1	0.712
p.N155I	WIL2-NS	haematopoietic_and_lymphoid_tissue	COSMIC	LETPKPS	DEG_SCF_FBW7_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LETPKPS

Degron related mutations and impact score

Drug responses associated with PSG7 mutations

All proteins holding degron of LETPKPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11464	Pregnancy-specific beta-1-glycoprotein 1	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.9956	More...
Q00888	Pregnancy-specific beta-1-glycoprotein 4	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.883	More...
Q9UQ72	Pregnancy-specific beta-1-glycoprotein 11	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.6282	More...
P11465	Pregnancy-specific beta-1-glycoprotein 2	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.8749	More...
Q13046	Putative pregnancy-specific beta-1-glycoprotein 7	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.9986	More...
Q16557	Pregnancy-specific beta-1-glycoprotein 3	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.9941	More...
Q9UQ74	Pregnancy-specific beta-1-glycoprotein 8	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.9298	More...