DegronMD - P11465(PSG2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G136A	TCGA-17-Z026	LUAD	TCGA	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1111
p.S315W	TCGA-17-Z031	LUAD	TCGA	TRIGLLPLL	DEG_APCC_DBOX_1	324:332	Mutation rewiring degron network	0.0833
p.L328H	TCGA-24-1842	OV	TCGA	TRIGLLPLL	DEG_APCC_DBOX_1	324:332	Mutation altering degron motif	0.7313
p.L328H	DO27972	OV	ICGC	TRIGLLPLL	DEG_APCC_DBOX_1	324:332	Mutation altering degron motif	0.7313
p.S321F	TCGA-33-4566	LUSC	TCGA	TRIGLLPLL	DEG_APCC_DBOX_1	324:332	Mutation blocking phosphorylation signal	0.6944
p.S321F	DO26790	LUSC	ICGC	TRIGLLPLL	DEG_APCC_DBOX_1	324:332	Mutation blocking phosphorylation signal	0.6944
p.S153I	TCGA-90-A59Q	LUSC	TCGA	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.25
p.S153I	DO50103	LUSC	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.25
p.L316M	TCGA-BF-A3DM	SKCM	TCGA	TRIGLLPLL	DEG_APCC_DBOX_1	324:332	Mutation rewiring degron network	0.1111
p.L316M	DO48667	SKCM	ICGC	TRIGLLPLL	DEG_APCC_DBOX_1	324:332	Mutation rewiring degron network	0.1111
p.L329P	TCGA-BR-6458	STAD	TCGA	TRIGLLPLL	DEG_APCC_DBOX_1	324:332	Mutation altering degron motif	0.6471
p.L329P	DO38296	STAD	ICGC	TRIGLLPLL	DEG_APCC_DBOX_1	324:332	Mutation altering degron motif	0.6471
p.S315L	TCGA-CA-6718	COAD	TCGA	TRIGLLPLL	DEG_APCC_DBOX_1	324:332	Mutation rewiring degron network	0.0833
p.S315L	DO7801	COAD	ICGC	TRIGLLPLL	DEG_APCC_DBOX_1	324:332	Mutation rewiring degron network	0.0833
p.S315L	DO229462	SKCA	ICGC	TRIGLLPLL	DEG_APCC_DBOX_1	324:332	Mutation rewiring degron network	0.0833
p.L329R	TCGA-CM-4743	COAD	TCGA	TRIGLLPLL	DEG_APCC_DBOX_1	324:332	Mutation altering degron motif	0.7316
p.L329R	DO8103	COAD	ICGC	TRIGLLPLL	DEG_APCC_DBOX_1	324:332	Mutation altering degron motif	0.7316
p.Y143H	TCGA-CR-7402	HNSC	TCGA	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.3056
p.Y143H	DO15727	HNSC	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.3056
p.G327R	TCGA-DA-A95Z	SKCM	TCGA	TRIGLLPLL	DEG_APCC_DBOX_1	324:332	Mutation altering degron motif	0.6457
p.G327R	DO219481	SKCM	ICGC	TRIGLLPLL	DEG_APCC_DBOX_1	324:332	Mutation altering degron motif	0.6457
p.L331V	TCGA-E6-A1LZ	UCEC	TCGA	TRIGLLPLL	DEG_APCC_DBOX_1	324:332	Mutation altering degron motif	0.5654
p.L331V	DO50934	LICA	ICGC	TRIGLLPLL	DEG_APCC_DBOX_1	324:332	Mutation altering degron motif	0.5654
p.L331V	DO41398	UCEC	ICGC	TRIGLLPLL	DEG_APCC_DBOX_1	324:332	Mutation altering degron motif	0.5654
p.G136E	TCGA-EB-A41A	SKCM	TCGA	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1111
p.G136E	TCGA-EE-A2GE	SKCM	TCGA	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1111
p.G136E	DO37429	SKCM	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1111
p.G136E	DO38016	SKCM	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1111
p.E160K	TCGA-EE-A182	SKCM	TCGA	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.0556
p.E160K	DO37814	SKCM	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.0556
p.E160K	SIDM00140	Melanoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.0556
p.E160K	ACH-000968	Skin Cancer	CCLE	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.0556
p.E160K	COLO-792	skin	COSMIC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.0556
p.S153N	TCGA-EE-A29E	SKCM	TCGA	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.25
p.S153N	DO37831	SKCM	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.25
p.S152F	TCGA-FR-A7U9	SKCM	TCGA	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.2778
p.S152F	DO48546	SKCM	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.2778
p.L329F	TCGA-FS-A1ZA	SKCM	TCGA	TRIGLLPLL	DEG_APCC_DBOX_1	324:332	Mutation altering degron motif	0.587
p.L329F	DO37551	SKCM	ICGC	TRIGLLPLL	DEG_APCC_DBOX_1	324:332	Mutation altering degron motif	0.587
p.L331F	TCGA-KQ-A41S	BLCA	TCGA	TRIGLLPLL	DEG_APCC_DBOX_1	324:332	Mutation altering degron motif	0.6981
p.L331F	DO223593	BLCA	ICGC	TRIGLLPLL	DEG_APCC_DBOX_1	324:332	Mutation altering degron motif	0.6981
p.S323C	DO225323	BRCA	ICGC	TRIGLLPLL	DEG_APCC_DBOX_1	324:332	Mutation blocking phosphorylation signal	0.75
p.P147R	DO228197	LICA	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.7512
p.T335K	DO229015	LICA	ICGC	TRIGLLPLL	DEG_APCC_DBOX_1	324:332	Mutation rewiring degron network	0.25
p.P334T	DO229022	LICA	ICGC	TRIGLLPLL	DEG_APCC_DBOX_1	324:332	Mutation rewiring degron network	0.2778
p.F140L	DO229045	LICA	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.2222
p.P330S	DO220891	MELA	ICGC	TRIGLLPLL	DEG_APCC_DBOX_1	324:332	Mutation altering degron motif	0.5641
p.R325I	DO35442	PACA	ICGC	TRIGLLPLL	DEG_APCC_DBOX_1	324:332	Mutation altering degron motif	0.8102
p.E145V	DO229446	SKCA	ICGC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.6582
p.N155K	SIDM01199	Hepatocellular Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1944
p.N155K	ACH-000493	Liver Cancer	CCLE	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1944
p.N155K	SNU-423	liver	COSMIC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1944
p.Y137C	SIDM00855	Other Sarcomas	GDSC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1389
p.Y137C	SIDM00846	Cervical Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1389
p.Y137C	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1389
p.Y137C	SIDM00694	Other Solid Cancers	GDSC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1389
p.Y137C	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1389
p.Y137C	SIDM00309	Mesothelioma	GDSC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1389
p.Y137C	SIDM00721	Small Cell Lung Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1389
p.Y137H	SIDM00855	Other Sarcomas	GDSC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1389
p.Y137H	SIDM00846	Cervical Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1389
p.Y137H	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1389
p.Y137H	SIDM00694	Other Solid Cancers	GDSC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1389
p.Y137H	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1389
p.Y137H	SIDM00309	Mesothelioma	GDSC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1389
p.Y137H	SIDM00721	Small Cell Lung Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.1389
p.V134L	SIDM01175	Other Sarcomas	GDSC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.0556
p.V134L	ACH-002309	Sarcoma	CCLE	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.0556
p.V134L	SW684	soft tissue	COSMIC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation rewiring degron network	0.0556
p.P330R	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	TRIGLLPLL	DEG_APCC_DBOX_1	324:332	Mutation altering degron motif	0.6401
p.P330R	ACH-000843	Lung Cancer	CCLE	TRIGLLPLL	DEG_APCC_DBOX_1	324:332	Mutation altering degron motif	0.6401
p.P330R	HARA	lung	COSMIC	TRIGLLPLL	DEG_APCC_DBOX_1	324:332	Mutation altering degron motif	0.6401
p.K148N	SIDM01045	Endometrial Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.5806
p.K148N	ACH-000978	Endometrial/Uterine Cancer	CCLE	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.5806
p.K148N	EN	endometrium	COSMIC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.5806
p.L144P	SIDM00228	Thyroid Gland Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	144:150	Mutation altering degron motif	0.6471

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PSG2

UniProt ID: P11465

Entrez ID: 5670

Protein name: Pregnancy-specific beta-1-glycoprotein 2 (PS-beta-G-2) (PSBG-2) (Pregnancy-specific glycoprotein 2) (Pregnancy-specific beta-1 glycoprotein E) (PS-beta-E)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PSG2 in