DegronMD

Uniprot ID: P11465

Source protein: Pregnancy-specific beta-1-glycoprotein 2

Source gene: PSG2

Class: DEG_APCC_DBOX_1

Location: 324:332

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9883

ASA_SCORE: 98.3889

COIL: 0.7163

CONS_SCORE: 0.6054

DSS_SCORE: 0.4729

HELIX: 0.018

FCONS_SCORE: 1.0319

RIG_SCORE: 0.7934

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S315W	TCGA-17-Z031	LUAD	TCGA	TRIGLLPLL	DEG_APCC_DBOX_1	0.0833
p.L328H	TCGA-24-1842	OV	TCGA	TRIGLLPLL	DEG_APCC_DBOX_1	0.7313
p.L328H	DO27972	OV	ICGC	TRIGLLPLL	DEG_APCC_DBOX_1	0.7313
p.S321F	TCGA-33-4566	LUSC	TCGA	TRIGLLPLL	DEG_APCC_DBOX_1	0.6944
p.S321F	DO26790	LUSC	ICGC	TRIGLLPLL	DEG_APCC_DBOX_1	0.6944
p.L316M	TCGA-BF-A3DM	SKCM	TCGA	TRIGLLPLL	DEG_APCC_DBOX_1	0.1111
p.L316M	DO48667	SKCM	ICGC	TRIGLLPLL	DEG_APCC_DBOX_1	0.1111
p.L329P	TCGA-BR-6458	STAD	TCGA	TRIGLLPLL	DEG_APCC_DBOX_1	0.6471
p.L329P	DO38296	STAD	ICGC	TRIGLLPLL	DEG_APCC_DBOX_1	0.6471
p.S315L	TCGA-CA-6718	COAD	TCGA	TRIGLLPLL	DEG_APCC_DBOX_1	0.0833
p.S315L	DO7801	COAD	ICGC	TRIGLLPLL	DEG_APCC_DBOX_1	0.0833
p.S315L	DO229462	SKCA	ICGC	TRIGLLPLL	DEG_APCC_DBOX_1	0.0833
p.L329R	TCGA-CM-4743	COAD	TCGA	TRIGLLPLL	DEG_APCC_DBOX_1	0.7316
p.L329R	DO8103	COAD	ICGC	TRIGLLPLL	DEG_APCC_DBOX_1	0.7316
p.G327R	TCGA-DA-A95Z	SKCM	TCGA	TRIGLLPLL	DEG_APCC_DBOX_1	0.6457
p.G327R	DO219481	SKCM	ICGC	TRIGLLPLL	DEG_APCC_DBOX_1	0.6457
p.L331V	TCGA-E6-A1LZ	UCEC	TCGA	TRIGLLPLL	DEG_APCC_DBOX_1	0.5654
p.L331V	DO50934	LICA	ICGC	TRIGLLPLL	DEG_APCC_DBOX_1	0.5654
p.L331V	DO41398	UCEC	ICGC	TRIGLLPLL	DEG_APCC_DBOX_1	0.5654
p.L329F	TCGA-FS-A1ZA	SKCM	TCGA	TRIGLLPLL	DEG_APCC_DBOX_1	0.587
p.L329F	DO37551	SKCM	ICGC	TRIGLLPLL	DEG_APCC_DBOX_1	0.587
p.L331F	TCGA-KQ-A41S	BLCA	TCGA	TRIGLLPLL	DEG_APCC_DBOX_1	0.6981
p.L331F	DO223593	BLCA	ICGC	TRIGLLPLL	DEG_APCC_DBOX_1	0.6981
p.S323C	DO225323	BRCA	ICGC	TRIGLLPLL	DEG_APCC_DBOX_1	0.75
p.T335K	DO229015	LICA	ICGC	TRIGLLPLL	DEG_APCC_DBOX_1	0.25
p.P334T	DO229022	LICA	ICGC	TRIGLLPLL	DEG_APCC_DBOX_1	0.2778
p.P330S	DO220891	MELA	ICGC	TRIGLLPLL	DEG_APCC_DBOX_1	0.5641
p.R325I	DO35442	PACA	ICGC	TRIGLLPLL	DEG_APCC_DBOX_1	0.8102
p.P330R	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	TRIGLLPLL	DEG_APCC_DBOX_1	0.6401
p.P330R	ACH-000843	Lung Cancer	CCLE	TRIGLLPLL	DEG_APCC_DBOX_1	0.6401
p.P330R	HARA	lung	COSMIC	TRIGLLPLL	DEG_APCC_DBOX_1	0.6401

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TRIGLLPLL

Degron related mutations and impact score

Drug responses associated with PSG2 mutations

All proteins holding degron of TRIGLLPLL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11465	Pregnancy-specific beta-1-glycoprotein 2	DEG_APCC_DBOX_1	324:332	TRIGLLPLL	APC,CDC20,FZR1	0.9883	More...