DegronMD

Uniprot ID: Q16557

Source protein: Pregnancy-specific beta-1-glycoprotein 3

Source gene: PSG3

Class: DEG_SCF_FBW7_1

Location: 144:150

E3 ligase: FBXW7

DEGRON score: 0.9941

ASA_SCORE: 76.2286

COIL: 0.7784

CONS_SCORE: 0.4108

DSS_SCORE: 0.3286

HELIX: 0.0156

FCONS_SCORE: 1.3773

RIG_SCORE: 0.76

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E145G	TCGA-AB-2808	LAML	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.6087
p.E145G	DO21487	LAML	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.6087
p.E160D	TCGA-AX-A2HA	UCEC	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.0556
p.E160D	TCGA-MI-A75G	LIHC	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.0556
p.E160D	DO49709	LIHC	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.0556
p.E160D	DO42504	UCEC	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.0556
p.S153G	TCGA-DU-5870	LGG	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.25
p.S153G	DO22199	LGG	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.25
p.L144V	TCGA-EE-A181	SKCM	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.5654
p.L144V	DO37444	SKCM	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.5654
p.N155S	TCGA-HU-A4GT	STAD	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.1944
p.N155S	DO48020	STAD	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.1944
p.E160K	TCGA-W3-A824	SKCM	TCGA	LETPKPS	DEG_SCF_FBW7_1	0.0556
p.E160K	DO220886	MELA	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.0556
p.E160K	DO51271	SKCM	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.0556
p.E160K	SIDM00545	Melanoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.0556
p.E160K	ACH-000987	Skin Cancer	CCLE	LETPKPS	DEG_SCF_FBW7_1	0.0556
p.E160K	Mewo	skin	COSMIC	LETPKPS	DEG_SCF_FBW7_1	0.0556
p.S154R	DO228978	LICA	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.2222
p.H137R	DO229050	LICA	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.1389
p.E134V	DO229053	LICA	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.0556
p.RE159RK	DO220886	MELA	ICGC	LETPKPS	DEG_SCF_FBW7_1	0
p.E145K	DO222749	MELA	ICGC	LETPKPS	DEG_SCF_FBW7_1	0.591
p.L156V	SIDM02019	Colorectal Carcinoma	GDSC	LETPKPS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P11464	Pregnancy-specific beta-1-glycoprotein 1	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.9956	More...
Q00888	Pregnancy-specific beta-1-glycoprotein 4	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.883	More...
Q9UQ72	Pregnancy-specific beta-1-glycoprotein 11	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.6282	More...
P11465	Pregnancy-specific beta-1-glycoprotein 2	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.8749	More...
Q13046	Putative pregnancy-specific beta-1-glycoprotein 7	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.9986	More...
Q16557	Pregnancy-specific beta-1-glycoprotein 3	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.9941	More...
Q9UQ74	Pregnancy-specific beta-1-glycoprotein 8	DEG_SCF_FBW7_1	144:150	LETPKPS	FBXW7	0.9298	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons