DegronMD - Q9UQF0(ERVW-1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V512F	TCGA-19-5956	GBM	TCGA	IKGTPPEE	DEG_SCF_FBW7_2	515:522	Mutation rewiring degron network	0.25
p.V512F	DO13863	GBM	ICGC	IKGTPPEE	DEG_SCF_FBW7_2	515:522	Mutation rewiring degron network	0.25
p.A526T	TCGA-38-4632	LUAD	TCGA	IKGTPPEE	DEG_SCF_FBW7_2	515:522	Mutation rewiring degron network	0.2222
p.A526T	DO23858	LUAD	ICGC	IKGTPPEE	DEG_SCF_FBW7_2	515:522	Mutation rewiring degron network	0.2222
p.R531C	TCGA-A5-A0G2	UCEC	TCGA	IKGTPPEE	DEG_SCF_FBW7_2	515:522	Mutation rewiring degron network	0.0833
p.R531C	DO224808	COCA	ICGC	IKGTPPEE	DEG_SCF_FBW7_2	515:522	Mutation rewiring degron network	0.0833
p.R531C	DO41235	UCEC	ICGC	IKGTPPEE	DEG_SCF_FBW7_2	515:522	Mutation rewiring degron network	0.0833
p.R531C	SIDM00855	Other Sarcomas	GDSC	IKGTPPEE	DEG_SCF_FBW7_2	515:522	Mutation rewiring degron network	0.0833
p.R531C	G-402	soft tissue	COSMIC	IKGTPPEE	DEG_SCF_FBW7_2	515:522	Mutation rewiring degron network	0.0833
p.E521D	TCGA-D1-A160	UCEC	TCGA	IKGTPPEE	DEG_SCF_FBW7_2	515:522	Mutation altering degron motif	0.5647
p.E521D	DO41626	UCEC	ICGC	IKGTPPEE	DEG_SCF_FBW7_2	515:522	Mutation altering degron motif	0.5647
p.E522K	TCGA-DA-A1I1	SKCM	TCGA	IKGTPPEE	DEG_SCF_FBW7_2	515:522	Mutation altering degron motif	0.7022
p.E522K	DO37966	SKCM	ICGC	IKGTPPEE	DEG_SCF_FBW7_2	515:522	Mutation altering degron motif	0.7022
p.E522K	ACH-002508	Skin Cancer	CCLE	IKGTPPEE	DEG_SCF_FBW7_2	515:522	Mutation altering degron motif	0.7022
p.S507G	TCGA-YD-A9TA	SKCM	TCGA	IKGTPPEE	DEG_SCF_FBW7_2	515:522	Mutation blocking phosphorylation signal	0.5556
p.S507G	DO219503	SKCM	ICGC	IKGTPPEE	DEG_SCF_FBW7_2	515:522	Mutation blocking phosphorylation signal	0.5556
p.R531S	DO229045	LICA	ICGC	IKGTPPEE	DEG_SCF_FBW7_2	515:522	Mutation rewiring degron network	0.0833
p.A525T	DO229051	LICA	ICGC	IKGTPPEE	DEG_SCF_FBW7_2	515:522	Mutation rewiring degron network	0.25
p.P508S	SIDM00149	Melanoma	GDSC	IKGTPPEE	DEG_SCF_FBW7_2	515:522	Mutation rewiring degron network	0.1389
p.P508S	ACH-000750	Skin Cancer	CCLE	IKGTPPEE	DEG_SCF_FBW7_2	515:522	Mutation rewiring degron network	0.1389
p.P508S	LOXIMVI	skin	COSMIC	IKGTPPEE	DEG_SCF_FBW7_2	515:522	Mutation rewiring degron network	0.1389
p.T518N	SIDM00063	Melanoma	GDSC	IKGTPPEE	DEG_SCF_FBW7_2	515:522	Mutation altering degron motif	0.8166
p.A526V	SIDM01779	Gastric Carcinoma	GDSC	IKGTPPEE	DEG_SCF_FBW7_2	515:522	Mutation rewiring degron network	0.2222
p.A526V	ACH-000761	Gastric Cancer	CCLE	IKGTPPEE	DEG_SCF_FBW7_2	515:522	Mutation rewiring degron network	0.2222

Kaplan plot for ERVW-1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ERVW-1

UniProt ID: Q9UQF0

Entrez ID: 30816

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ERVW-1 in