DegronMD

Uniprot ID: Q9UQF0

Source protein: Syncytin-1

Source gene: ERVW-1

Class: DEG_SCF_FBW7_2

Location: 515:522

E3 ligase: FBXW7

DEGRON score: 0.991

ASA_SCORE: 85.575

COIL: 0.803

CONS_SCORE: 1

DSS_SCORE: 0.6964

HELIX: 0.1681

FCONS_SCORE: 1.1

RIG_SCORE: 0.6423

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V512F	TCGA-19-5956	GBM	TCGA	IKGTPPEE	DEG_SCF_FBW7_2	0.25
p.V512F	DO13863	GBM	ICGC	IKGTPPEE	DEG_SCF_FBW7_2	0.25
p.A526T	TCGA-38-4632	LUAD	TCGA	IKGTPPEE	DEG_SCF_FBW7_2	0.2222
p.A526T	DO23858	LUAD	ICGC	IKGTPPEE	DEG_SCF_FBW7_2	0.2222
p.R531C	TCGA-A5-A0G2	UCEC	TCGA	IKGTPPEE	DEG_SCF_FBW7_2	0.0833
p.R531C	DO224808	COCA	ICGC	IKGTPPEE	DEG_SCF_FBW7_2	0.0833
p.R531C	DO41235	UCEC	ICGC	IKGTPPEE	DEG_SCF_FBW7_2	0.0833
p.R531C	SIDM00855	Other Sarcomas	GDSC	IKGTPPEE	DEG_SCF_FBW7_2	0.0833
p.R531C	G-402	soft_tissue	COSMIC	IKGTPPEE	DEG_SCF_FBW7_2	0.0833
p.E521D	TCGA-D1-A160	UCEC	TCGA	IKGTPPEE	DEG_SCF_FBW7_2	0.5647
p.E521D	DO41626	UCEC	ICGC	IKGTPPEE	DEG_SCF_FBW7_2	0.5647
p.E522K	TCGA-DA-A1I1	SKCM	TCGA	IKGTPPEE	DEG_SCF_FBW7_2	0.7022
p.E522K	DO37966	SKCM	ICGC	IKGTPPEE	DEG_SCF_FBW7_2	0.7022
p.E522K	ACH-002508	Skin Cancer	CCLE	IKGTPPEE	DEG_SCF_FBW7_2	0.7022
p.S507G	TCGA-YD-A9TA	SKCM	TCGA	IKGTPPEE	DEG_SCF_FBW7_2	0.5556
p.S507G	DO219503	SKCM	ICGC	IKGTPPEE	DEG_SCF_FBW7_2	0.5556
p.R531S	DO229045	LICA	ICGC	IKGTPPEE	DEG_SCF_FBW7_2	0.0833
p.A525T	DO229051	LICA	ICGC	IKGTPPEE	DEG_SCF_FBW7_2	0.25
p.P508S	SIDM00149	Melanoma	GDSC	IKGTPPEE	DEG_SCF_FBW7_2	0.1389
p.P508S	ACH-000750	Skin Cancer	CCLE	IKGTPPEE	DEG_SCF_FBW7_2	0.1389
p.P508S	LOXIMVI	skin	COSMIC	IKGTPPEE	DEG_SCF_FBW7_2	0.1389
p.T518N	SIDM00063	Melanoma	GDSC	IKGTPPEE	DEG_SCF_FBW7_2	0.8166
p.A526V	SIDM01779	Gastric Carcinoma	GDSC	IKGTPPEE	DEG_SCF_FBW7_2	0.2222
p.A526V	ACH-000761	Gastric Cancer	CCLE	IKGTPPEE	DEG_SCF_FBW7_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UQF0	Syncytin-1	DEG_SCF_FBW7_2	515:522	IKGTPPEE	FBXW7	0.991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons