DegronMD - Q9UQQ1(NAALADL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V213M	TCGA-A8-A09E	BRCA	TCGA	VLVYTD	LIG_APCC_ABBA_1	213:218	Mutation altering degron motif	0.6097
p.V213M	DO3334	BRCA	ICGC	VLVYTD	LIG_APCC_ABBA_1	213:218	Mutation altering degron motif	0.6097
p.D221N	TCGA-D5-5538	COAD	TCGA	VLVYTD	LIG_APCC_ABBA_1	213:218	Mutation rewiring degron network	0.25
p.D221N	DO8962	COAD	ICGC	VLVYTD	LIG_APCC_ABBA_1	213:218	Mutation rewiring degron network	0.25
p.G209V	TCGA-ER-A19P	SKCM	TCGA	VLVYTD	LIG_APCC_ABBA_1	213:218	Mutation rewiring degron network	0.2222
p.G209V	DO47623	SKCM	ICGC	VLVYTD	LIG_APCC_ABBA_1	213:218	Mutation rewiring degron network	0.2222
p.P219T	TCGA-G7-6797	KIRP	TCGA	VLVYTD	LIG_APCC_ABBA_1	213:218	Mutation rewiring degron network	0.3056
p.P219T	DO20917	KIRP	ICGC	VLVYTD	LIG_APCC_ABBA_1	213:218	Mutation rewiring degron network	0.3056
p.R205Q	DO49763	BLCA	ICGC	VLVYTD	LIG_APCC_ABBA_1	213:218	Mutation rewiring degron network	0.1111
p.R205Q	DO44049	BLCA	ICGC	VLVYTD	LIG_APCC_ABBA_1	213:218	Mutation rewiring degron network	0.1111
p.R205Q	DO219093	BLCA	ICGC	VLVYTD	LIG_APCC_ABBA_1	213:218	Mutation rewiring degron network	0.1111
p.R205Q	DO227629	BRCA	ICGC	VLVYTD	LIG_APCC_ABBA_1	213:218	Mutation rewiring degron network	0.1111
p.R205Q	DO26536	LUSC	ICGC	VLVYTD	LIG_APCC_ABBA_1	213:218	Mutation rewiring degron network	0.1111
p.R205Q	DO232070	ORCA	ICGC	VLVYTD	LIG_APCC_ABBA_1	213:218	Mutation rewiring degron network	0.1111
p.R205Q	ACH-000951	Lung Cancer	CCLE	VLVYTD	LIG_APCC_ABBA_1	213:218	Mutation rewiring degron network	0.1111
p.R205Q	NCI-H2342	lung	COSMIC	VLVYTD	LIG_APCC_ABBA_1	213:218	Mutation rewiring degron network	0.1111
p.R228H	DO228296	EOPC	ICGC	VLVYTD	LIG_APCC_ABBA_1	213:218	Mutation rewiring degron network	0.0556
p.R228H	ACH-000997	Colon/Colorectal Cancer	CCLE	VLVYTD	LIG_APCC_ABBA_1	213:218	Mutation rewiring degron network	0.0556
p.R228H	ACH-001061	Colon/Colorectal Cancer	CCLE	VLVYTD	LIG_APCC_ABBA_1	213:218	Mutation rewiring degron network	0.0556
p.R228H	HCT-15	large intestine	COSMIC	VLVYTD	LIG_APCC_ABBA_1	213:218	Mutation rewiring degron network	0.0556
p.E204V	DO233709	GACA	ICGC	VLVYTD	LIG_APCC_ABBA_1	213:218	Mutation rewiring degron network	0.0833
p.Y208H	DO50966	LICA	ICGC	VLVYTD	LIG_APCC_ABBA_1	213:218	Mutation rewiring degron network	0.1944
p.G209E	SIDM01144	Gastric Carcinoma	GDSC	VLVYTD	LIG_APCC_ABBA_1	213:218	Mutation rewiring degron network	0.2222
p.G209E	SIDM00581	Glioblastoma	GDSC	VLVYTD	LIG_APCC_ABBA_1	213:218	Mutation rewiring degron network	0.2222
p.G209E	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	VLVYTD	LIG_APCC_ABBA_1	213:218	Mutation rewiring degron network	0.2222
p.G209E	SIDM00162	Biliary Tract Carcinoma	GDSC	VLVYTD	LIG_APCC_ABBA_1	213:218	Mutation rewiring degron network	0.2222
p.G209E	SIDM01343	Gastric Carcinoma	GDSC	VLVYTD	LIG_APCC_ABBA_1	213:218	Mutation rewiring degron network	0.2222
p.T217S	ACH-000135	Non-Cancerous	CCLE	VLVYTD	LIG_APCC_ABBA_1	213:218	Mutation altering degron motif	0.6005
p.A222T	ACH-002256	Leukemia	CCLE	VLVYTD	LIG_APCC_ABBA_1	213:218	Mutation rewiring degron network	0.2222
p.A222T	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VLVYTD	LIG_APCC_ABBA_1	213:218	Mutation rewiring degron network	0.2222

Kaplan plot for NAALADL1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NAALADL1

UniProt ID: Q9UQQ1

Entrez ID: 10004

Protein name: Aminopeptidase NAALADL1 (EC 3.4.11.-) (100 kDa ileum brush border membrane protein) (I100) (Ileal dipeptidylpeptidase) (N-acetylated-alpha-linked acidic dipeptidase-like protein) (NAALADase L)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NAALADL1 in