DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VLVYTD
Uniprot ID:
Q9UQQ1
Source protein:
Aminopeptidase NAALADL1
Source gene:
NAALADL1
Class:
LIG_APCC_ABBA_1
Location:
213:218
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.5469
ASA_SCORE:
8.1333
COIL:
0.347
CONS_SCORE:
0.674
DSS_SCORE:
0.2611
HELIX:
0.0027
FCONS_SCORE:
1.3957
RIG_SCORE:
0.855
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.V213M
TCGA-A8-A09E
BRCA
TCGA
VLVYTD
LIG_APCC_ABBA_1
0.6097
p.V213M
DO3334
BRCA
ICGC
VLVYTD
LIG_APCC_ABBA_1
0.6097
p.T217S
ACH-000135
Non-Cancerous
CCLE
VLVYTD
LIG_APCC_ABBA_1
0.6005
p.P219T
TCGA-G7-6797
KIRP
TCGA
VLVYTD
LIG_APCC_ABBA_1
0.3056
p.P219T
DO20917
KIRP
ICGC
VLVYTD
LIG_APCC_ABBA_1
0.3056
p.D221N
TCGA-D5-5538
COAD
TCGA
VLVYTD
LIG_APCC_ABBA_1
0.25
p.D221N
DO8962
COAD
ICGC
VLVYTD
LIG_APCC_ABBA_1
0.25
p.G209V
TCGA-ER-A19P
SKCM
TCGA
VLVYTD
LIG_APCC_ABBA_1
0.2222
p.G209V
DO47623
SKCM
ICGC
VLVYTD
LIG_APCC_ABBA_1
0.2222
p.G209E
SIDM01144
Gastric Carcinoma
GDSC
VLVYTD
LIG_APCC_ABBA_1
0.2222
p.G209E
SIDM00581
Glioblastoma
GDSC
VLVYTD
LIG_APCC_ABBA_1
0.2222
p.G209E
SIDM00374
B-Cell Non-Hodgkin's Lymphoma
GDSC
VLVYTD
LIG_APCC_ABBA_1
0.2222
p.G209E
SIDM00162
Biliary Tract Carcinoma
GDSC
VLVYTD
LIG_APCC_ABBA_1
0.2222
p.G209E
SIDM01343
Gastric Carcinoma
GDSC
VLVYTD
LIG_APCC_ABBA_1
0.2222
p.A222T
ACH-002256
Leukemia
CCLE
VLVYTD
LIG_APCC_ABBA_1
0.2222
p.A222T
KARPAS-45
haematopoietic_and_lymphoid_tissue
COSMIC
VLVYTD
LIG_APCC_ABBA_1
0.2222
p.Y208H
DO50966
LICA
ICGC
VLVYTD
LIG_APCC_ABBA_1
0.1944
p.R205Q
DO49763
BLCA
ICGC
VLVYTD
LIG_APCC_ABBA_1
0.1111
p.R205Q
DO44049
BLCA
ICGC
VLVYTD
LIG_APCC_ABBA_1
0.1111
p.R205Q
DO219093
BLCA
ICGC
VLVYTD
LIG_APCC_ABBA_1
0.1111
p.R205Q
DO227629
BRCA
ICGC
VLVYTD
LIG_APCC_ABBA_1
0.1111
p.R205Q
DO26536
LUSC
ICGC
VLVYTD
LIG_APCC_ABBA_1
0.1111
p.R205Q
DO232070
ORCA
ICGC
VLVYTD
LIG_APCC_ABBA_1
0.1111
p.R205Q
ACH-000951
Lung Cancer
CCLE
VLVYTD
LIG_APCC_ABBA_1
0.1111
p.R205Q
NCI-H2342
lung
COSMIC
VLVYTD
LIG_APCC_ABBA_1
0.1111
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Drug responses associated with NAALADL1 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of VLVYTD
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9UQQ1
Aminopeptidase NAALADL1
LIG_APCC_ABBA_1
213:218
VLVYTD
APC,CDC20,FZR1
0.5469
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