DegronMD

Uniprot ID: Q9UQQ1

Source protein: Aminopeptidase NAALADL1

Source gene: NAALADL1

Class: LIG_APCC_ABBA_1

Location: 213:218

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5469

ASA_SCORE: 8.1333

COIL: 0.347

CONS_SCORE: 0.674

DSS_SCORE: 0.2611

HELIX: 0.0027

FCONS_SCORE: 1.3957

RIG_SCORE: 0.855

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V213M	TCGA-A8-A09E	BRCA	TCGA	VLVYTD	LIG_APCC_ABBA_1	0.6097
p.V213M	DO3334	BRCA	ICGC	VLVYTD	LIG_APCC_ABBA_1	0.6097
p.D221N	TCGA-D5-5538	COAD	TCGA	VLVYTD	LIG_APCC_ABBA_1	0.25
p.D221N	DO8962	COAD	ICGC	VLVYTD	LIG_APCC_ABBA_1	0.25
p.G209V	TCGA-ER-A19P	SKCM	TCGA	VLVYTD	LIG_APCC_ABBA_1	0.2222
p.G209V	DO47623	SKCM	ICGC	VLVYTD	LIG_APCC_ABBA_1	0.2222
p.P219T	TCGA-G7-6797	KIRP	TCGA	VLVYTD	LIG_APCC_ABBA_1	0.3056
p.P219T	DO20917	KIRP	ICGC	VLVYTD	LIG_APCC_ABBA_1	0.3056
p.R205Q	DO49763	BLCA	ICGC	VLVYTD	LIG_APCC_ABBA_1	0.1111
p.R205Q	DO44049	BLCA	ICGC	VLVYTD	LIG_APCC_ABBA_1	0.1111
p.R205Q	DO219093	BLCA	ICGC	VLVYTD	LIG_APCC_ABBA_1	0.1111
p.R205Q	DO227629	BRCA	ICGC	VLVYTD	LIG_APCC_ABBA_1	0.1111
p.R205Q	DO26536	LUSC	ICGC	VLVYTD	LIG_APCC_ABBA_1	0.1111
p.R205Q	DO232070	ORCA	ICGC	VLVYTD	LIG_APCC_ABBA_1	0.1111
p.R205Q	ACH-000951	Lung Cancer	CCLE	VLVYTD	LIG_APCC_ABBA_1	0.1111
p.R205Q	NCI-H2342	lung	COSMIC	VLVYTD	LIG_APCC_ABBA_1	0.1111
p.R228H	DO228296	EOPC	ICGC	VLVYTD	LIG_APCC_ABBA_1	0.0556
p.R228H	ACH-000997	Colon/Colorectal Cancer	CCLE	VLVYTD	LIG_APCC_ABBA_1	0.0556
p.R228H	ACH-001061	Colon/Colorectal Cancer	CCLE	VLVYTD	LIG_APCC_ABBA_1	0.0556
p.R228H	HCT-15	large_intestine	COSMIC	VLVYTD	LIG_APCC_ABBA_1	0.0556
p.E204V	DO233709	GACA	ICGC	VLVYTD	LIG_APCC_ABBA_1	0.0833
p.Y208H	DO50966	LICA	ICGC	VLVYTD	LIG_APCC_ABBA_1	0.1944
p.G209E	SIDM01144	Gastric Carcinoma	GDSC	VLVYTD	LIG_APCC_ABBA_1	0.2222
p.G209E	SIDM00581	Glioblastoma	GDSC	VLVYTD	LIG_APCC_ABBA_1	0.2222
p.G209E	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	VLVYTD	LIG_APCC_ABBA_1	0.2222
p.G209E	SIDM00162	Biliary Tract Carcinoma	GDSC	VLVYTD	LIG_APCC_ABBA_1	0.2222
p.G209E	SIDM01343	Gastric Carcinoma	GDSC	VLVYTD	LIG_APCC_ABBA_1	0.2222
p.T217S	ACH-000135	Non-Cancerous	CCLE	VLVYTD	LIG_APCC_ABBA_1	0.6005
p.A222T	ACH-002256	Leukemia	CCLE	VLVYTD	LIG_APCC_ABBA_1	0.2222
p.A222T	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VLVYTD	LIG_APCC_ABBA_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VLVYTD

Degron related mutations and impact score

Drug responses associated with NAALADL1 mutations

All proteins holding degron of VLVYTD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UQQ1	Aminopeptidase NAALADL1	LIG_APCC_ABBA_1	213:218	VLVYTD	APC,CDC20,FZR1	0.5469	More...