DegronMD - Q9UQV4(LAMP3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N93S	TCGA-06-5416	GBM	TCGA	PTTTPATT	DEG_SCF_FBW7_1	84:91	Mutation rewiring degron network	0.2778
p.N93S	TCGA-A3-3387	KIRC	TCGA	PTTTPATT	DEG_SCF_FBW7_1	84:91	Mutation rewiring degron network	0.2778
p.N93S	SIDM00676	Bladder Carcinoma	GDSC	PTTTPATT	DEG_SCF_FBW7_1	84:91	Mutation rewiring degron network	0.2778
p.N93S	HT-1197	urinary tract	COSMIC	PTTTPATT	DEG_SCF_FBW7_1	84:91	Mutation rewiring degron network	0.2778
p.Q76K	TCGA-2F-A9KR	BLCA	TCGA	PTTTPATT	DEG_SCF_FBW7_1	84:91	Mutation rewiring degron network	0.1111
p.S98R	TCGA-85-7843	LUSC	TCGA	PTTTPATT	DEG_SCF_FBW7_1	84:91	Mutation rewiring degron network	0.1389
p.T74A	TCGA-A5-A2K5	UCEC	TCGA	PTTTPATT	DEG_SCF_FBW7_1	84:91	Mutation rewiring degron network	0.0556
p.K92I	TCGA-FS-A1ZZ	SKCM	TCGA	PTTTPATT	DEG_SCF_FBW7_1	84:91	Mutation rewiring degron network	0.3056
p.A78V	TCGA-JY-A6FA	ESCA	TCGA	PTTTPATT	DEG_SCF_FBW7_1	84:91	Mutation rewiring degron network	0.1667
p.P94H	DO233784	GACA	ICGC	PTTTPATT	DEG_SCF_FBW7_1	84:91	Mutation rewiring degron network	0.25
p.S74R	DO26500	LUSC	ICGC	PTTTPATT	DEG_SCF_FBW7_1	84:91	Mutation rewiring degron network	0.0556
p.L80V	DO26566	LUSC	ICGC	PTTTPATT	DEG_SCF_FBW7_1	84:91	Mutation rewiring degron network	0.2222
p.T80I	SIDM02021	Esophageal Carcinoma	GDSC	PTTTPATT	DEG_SCF_FBW7_1	84:91	Mutation rewiring degron network	0.2222
p.T85I	SIDM00491	Thyroid Gland Carcinoma	GDSC	PTTTPATT	DEG_SCF_FBW7_1	84:91	Mutation altering degron motif	0.5966
p.T85I	ASH-3	thyroid	COSMIC	PTTTPATT	DEG_SCF_FBW7_1	84:91	Mutation altering degron motif	0.5966
p.A95V	SIDM00263	Ewing's Sarcoma	GDSC	PTTTPATT	DEG_SCF_FBW7_1	84:91	Mutation rewiring degron network	0.2222
p.A95V	ES5	bone	COSMIC	PTTTPATT	DEG_SCF_FBW7_1	84:91	Mutation rewiring degron network	0.2222
p.P88A	SIDM00753	Squamous Cell Lung Carcinoma	GDSC	PTTTPATT	DEG_SCF_FBW7_1	84:91	Mutation altering degron motif	0.7503
p.P88A	NCI-H2023	lung	COSMIC	PTTTPATT	DEG_SCF_FBW7_1	84:91	Mutation altering degron motif	0.7503
p.P95L	ACH-000824	Esophageal Cancer	CCLE	PTTTPATT	DEG_SCF_FBW7_1	84:91	Mutation rewiring degron network	0.2222
p.P95L	KYSE-510	oesophagus	COSMIC	PTTTPATT	DEG_SCF_FBW7_1	84:91	Mutation rewiring degron network	0.2222
p.P95S	ACH-000824	Esophageal Cancer	CCLE	PTTTPATT	DEG_SCF_FBW7_1	84:91	Mutation rewiring degron network	0.2222
p.P95S	KYSE-510	oesophagus	COSMIC	PTTTPATT	DEG_SCF_FBW7_1	84:91	Mutation rewiring degron network	0.2222

Kaplan plot for LAMP3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LAMP3

UniProt ID: Q9UQV4

Entrez ID: 27074

Protein name: Lysosome-associated membrane glycoprotein 3 (LAMP-3) (Lysosomal-associated membrane protein 3) (DC-lysosome-associated membrane glycoprotein) (DC LAMP) (Protein TSC403) (CD antigen CD208)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LAMP3 in