DegronMD

Uniprot ID: Q9UQV4

Source protein: Lysosome-associated membrane glycoprotein 3

Source gene: LAMP3

Class: DEG_SCF_FBW7_1

Location: 84:91

E3 ligase: FBXW7

DEGRON score: 0.9961

ASA_SCORE: 79.125

COIL: 0.7769

CONS_SCORE: 0.6911

DSS_SCORE: 0.4787

HELIX: 0.0168

FCONS_SCORE: 1.3199

RIG_SCORE: 0.7588

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N93S	TCGA-06-5416	GBM	TCGA	PTTTPATT	DEG_SCF_FBW7_1	0.2778
p.N93S	TCGA-A3-3387	KIRC	TCGA	PTTTPATT	DEG_SCF_FBW7_1	0.2778
p.N93S	SIDM00676	Bladder Carcinoma	GDSC	PTTTPATT	DEG_SCF_FBW7_1	0.2778
p.N93S	HT-1197	urinary_tract	COSMIC	PTTTPATT	DEG_SCF_FBW7_1	0.2778
p.Q76K	TCGA-2F-A9KR	BLCA	TCGA	PTTTPATT	DEG_SCF_FBW7_1	0.1111
p.S98R	TCGA-85-7843	LUSC	TCGA	PTTTPATT	DEG_SCF_FBW7_1	0.1389
p.T74A	TCGA-A5-A2K5	UCEC	TCGA	PTTTPATT	DEG_SCF_FBW7_1	0.0556
p.K92I	TCGA-FS-A1ZZ	SKCM	TCGA	PTTTPATT	DEG_SCF_FBW7_1	0.3056
p.A78V	TCGA-JY-A6FA	ESCA	TCGA	PTTTPATT	DEG_SCF_FBW7_1	0.1667
p.P94H	DO233784	GACA	ICGC	PTTTPATT	DEG_SCF_FBW7_1	0.25
p.S74R	DO26500	LUSC	ICGC	PTTTPATT	DEG_SCF_FBW7_1	0.0556
p.L80V	DO26566	LUSC	ICGC	PTTTPATT	DEG_SCF_FBW7_1	0.2222
p.T80I	SIDM02021	Esophageal Carcinoma	GDSC	PTTTPATT	DEG_SCF_FBW7_1	0.2222
p.T85I	SIDM00491	Thyroid Gland Carcinoma	GDSC	PTTTPATT	DEG_SCF_FBW7_1	0.5966
p.T85I	ASH-3	thyroid	COSMIC	PTTTPATT	DEG_SCF_FBW7_1	0.5966
p.A95V	SIDM00263	Ewing's Sarcoma	GDSC	PTTTPATT	DEG_SCF_FBW7_1	0.2222
p.A95V	ES5	bone	COSMIC	PTTTPATT	DEG_SCF_FBW7_1	0.2222
p.P88A	SIDM00753	Squamous Cell Lung Carcinoma	GDSC	PTTTPATT	DEG_SCF_FBW7_1	0.7503
p.P88A	NCI-H2023	lung	COSMIC	PTTTPATT	DEG_SCF_FBW7_1	0.7503
p.P95L	ACH-000824	Esophageal Cancer	CCLE	PTTTPATT	DEG_SCF_FBW7_1	0.2222
p.P95L	KYSE-510	oesophagus	COSMIC	PTTTPATT	DEG_SCF_FBW7_1	0.2222
p.P95S	ACH-000824	Esophageal Cancer	CCLE	PTTTPATT	DEG_SCF_FBW7_1	0.2222
p.P95S	KYSE-510	oesophagus	COSMIC	PTTTPATT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UQV4	Lysosome-associated membrane glycoprotein 3	DEG_SCF_FBW7_1	84:91	PTTTPATT	FBXW7	0.9961	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons