DegronMD - Q9Y248(GINS2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T172M	TCGA-AA-3831	COAD	TCGA	LRTNLQPLE	DEG_APCC_DBOX_1	170:178	Mutation altering degron motif	0.6312
p.T172M	DO8538	COAD	ICGC	LRTNLQPLE	DEG_APCC_DBOX_1	170:178	Mutation altering degron motif	0.6312
p.S182P	TCGA-AD-6889	COAD	TCGA	LRTNLQPLE	DEG_APCC_DBOX_1	170:178	Mutation blocking phosphorylation signal	0.6667
p.S182P	DO8463	COAD	ICGC	LRTNLQPLE	DEG_APCC_DBOX_1	170:178	Mutation blocking phosphorylation signal	0.6667
p.F185L	TCGA-IR-A3LH	CESC	TCGA	LRTNLQPLE	DEG_APCC_DBOX_1	170:178	Mutation rewiring degron network	0.1389
p.F185L	DO44381	CESC	ICGC	LRTNLQPLE	DEG_APCC_DBOX_1	170:178	Mutation rewiring degron network	0.1389
p.N173K	DO228974	LICA	ICGC	LRTNLQPLE	DEG_APCC_DBOX_1	170:178	Mutation altering degron motif	0.5806
p.A163E	DO229019	LICA	ICGC	LRTNLQPLE	DEG_APCC_DBOX_1	170:178	Mutation rewiring degron network	0.1389
p.D184G	SIDM01175	Other Sarcomas	GDSC	LRTNLQPLE	DEG_APCC_DBOX_1	170:178	Mutation rewiring degron network	0.1667
p.D184G	ACH-002309	Sarcoma	CCLE	LRTNLQPLE	DEG_APCC_DBOX_1	170:178	Mutation rewiring degron network	0.1667
p.D184G	SW684	soft tissue	COSMIC	LRTNLQPLE	DEG_APCC_DBOX_1	170:178	Mutation rewiring degron network	0.1667
p.L170F	SIDM00217	Colorectal Carcinoma	GDSC	LRTNLQPLE	DEG_APCC_DBOX_1	170:178	Mutation altering degron motif	0.587
p.L170F	ACH-000999	Colon/Colorectal Cancer	CCLE	LRTNLQPLE	DEG_APCC_DBOX_1	170:178	Mutation altering degron motif	0.587
p.L170F	SNU-1040	large intestine	COSMIC	LRTNLQPLE	DEG_APCC_DBOX_1	170:178	Mutation altering degron motif	0.587

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons