DegronMD

Uniprot ID: Q9Y248

Source protein: DNA replication complex GINS protein PSF2

Source gene: GINS2

Class: DEG_APCC_DBOX_1

Location: 170:178

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6832

ASA_SCORE: 95.7556

COIL: 0.6483

CONS_SCORE: 0.3021

DSS_SCORE: 0.4026

HELIX: 0.3399

FCONS_SCORE: 0.7945

RIG_SCORE: 0.781

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T172M	TCGA-AA-3831	COAD	TCGA	LRTNLQPLE	DEG_APCC_DBOX_1	0.6312
p.T172M	DO8538	COAD	ICGC	LRTNLQPLE	DEG_APCC_DBOX_1	0.6312
p.S182P	TCGA-AD-6889	COAD	TCGA	LRTNLQPLE	DEG_APCC_DBOX_1	0.6667
p.S182P	DO8463	COAD	ICGC	LRTNLQPLE	DEG_APCC_DBOX_1	0.6667
p.F185L	TCGA-IR-A3LH	CESC	TCGA	LRTNLQPLE	DEG_APCC_DBOX_1	0.1389
p.F185L	DO44381	CESC	ICGC	LRTNLQPLE	DEG_APCC_DBOX_1	0.1389
p.N173K	DO228974	LICA	ICGC	LRTNLQPLE	DEG_APCC_DBOX_1	0.5806
p.A163E	DO229019	LICA	ICGC	LRTNLQPLE	DEG_APCC_DBOX_1	0.1389
p.D184G	SIDM01175	Other Sarcomas	GDSC	LRTNLQPLE	DEG_APCC_DBOX_1	0.1667
p.D184G	ACH-002309	Sarcoma	CCLE	LRTNLQPLE	DEG_APCC_DBOX_1	0.1667
p.D184G	SW684	soft_tissue	COSMIC	LRTNLQPLE	DEG_APCC_DBOX_1	0.1667
p.L170F	SIDM00217	Colorectal Carcinoma	GDSC	LRTNLQPLE	DEG_APCC_DBOX_1	0.587
p.L170F	ACH-000999	Colon/Colorectal Cancer	CCLE	LRTNLQPLE	DEG_APCC_DBOX_1	0.587
p.L170F	SNU-1040	large_intestine	COSMIC	LRTNLQPLE	DEG_APCC_DBOX_1	0.587

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y248	DNA replication complex GINS protein PSF2	DEG_APCC_DBOX_1	170:178	LRTNLQPLE	APC,CDC20,FZR1	0.6832	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons