DegronMD - Q9Y252(RNF6)

RNF6

UniProt ID: Q9Y252

Entrez ID: 6049

Protein name: E3 ubiquitin-protein ligase RNF6 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase RNF6)

External links: UniprotKB HGNC RefSeq COSMIC

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GO - Biological processes (BP): View more >>

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GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R346K	TCGA-85-8072	LUSC	TCGA	RTRVFLE	LIG_APCC_ABBAyCdc20_2	346:352	Mutation altering degron motif	0.6126
p.R346K	DO27667	LUSC	ICGC	RTRVFLE	LIG_APCC_ABBAyCdc20_2	346:352	Mutation altering degron motif	0.6126
p.R360S	TCGA-AJ-A5DW	UCEC	TCGA	RTRVFLE	LIG_APCC_ABBAyCdc20_2	346:352	Mutation rewiring degron network	0.1111
p.R360S	DO50075	UCEC	ICGC	RTRVFLE	LIG_APCC_ABBAyCdc20_2	346:352	Mutation rewiring degron network	0.1111
p.R359H	TCGA-AP-A1DR	UCEC	TCGA	RTRVFLE	LIG_APCC_ABBAyCdc20_2	346:352	Mutation rewiring degron network	0.1389
p.R359H	TCGA-CD-A4MG	STAD	TCGA	RTRVFLE	LIG_APCC_ABBAyCdc20_2	346:352	Mutation rewiring degron network	0.1389
p.R359H	DO48009	STAD	ICGC	RTRVFLE	LIG_APCC_ABBAyCdc20_2	346:352	Mutation rewiring degron network	0.1389
p.R359H	DO43747	UCEC	ICGC	RTRVFLE	LIG_APCC_ABBAyCdc20_2	346:352	Mutation rewiring degron network	0.1389
p.R359C	TCGA-D1-A17Q	UCEC	TCGA	RTRVFLE	LIG_APCC_ABBAyCdc20_2	346:352	Mutation rewiring degron network	0.1389
p.R359C	DO41903	UCEC	ICGC	RTRVFLE	LIG_APCC_ABBAyCdc20_2	346:352	Mutation rewiring degron network	0.1389
p.R357Q	TCGA-D7-8579	STAD	TCGA	RTRVFLE	LIG_APCC_ABBAyCdc20_2	346:352	Mutation rewiring degron network	0.1944
p.R357Q	DO47985	STAD	ICGC	RTRVFLE	LIG_APCC_ABBAyCdc20_2	346:352	Mutation rewiring degron network	0.1944
p.G345C	TCGA-VQ-A8P2	STAD	TCGA	RTRVFLE	LIG_APCC_ABBAyCdc20_2	346:352	Mutation rewiring degron network	0.3056
p.G345C	DO51761	STAD	ICGC	RTRVFLE	LIG_APCC_ABBAyCdc20_2	346:352	Mutation rewiring degron network	0.3056
p.T362N	DO229019	LICA	ICGC	RTRVFLE	LIG_APCC_ABBAyCdc20_2	346:352	Mutation rewiring degron network	0.0556
p.Q353K	DO229035	LICA	ICGC	RTRVFLE	LIG_APCC_ABBAyCdc20_2	346:352	Mutation rewiring degron network	0.3056
p.T362A	ACH-001610	Brain Cancer	CCLE	RTRVFLE	LIG_APCC_ABBAyCdc20_2	346:352	Mutation rewiring degron network	0.0556

Kaplan plot for RNF6 in

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*NOTE: the Kaplan plots were collected from OncoLnc