DegronMD

Uniprot ID: Q9Y252

Source protein: E3 ubiquitin-protein ligase RNF6

Source gene: RNF6

Class: LIG_APCC_ABBAyCdc20_2

Location: 346:352

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9671

ASA_SCORE: 120.0143

COIL: 0.6893

CONS_SCORE: 0.4406

DSS_SCORE: 0.5552

HELIX: 0.2587

FCONS_SCORE: 1.0726

RIG_SCORE: 0.7729

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R346K	TCGA-85-8072	LUSC	TCGA	RTRVFLE	LIG_APCC_ABBAyCdc20_2	0.6126
p.R346K	DO27667	LUSC	ICGC	RTRVFLE	LIG_APCC_ABBAyCdc20_2	0.6126
p.R360S	TCGA-AJ-A5DW	UCEC	TCGA	RTRVFLE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R360S	DO50075	UCEC	ICGC	RTRVFLE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R359H	TCGA-AP-A1DR	UCEC	TCGA	RTRVFLE	LIG_APCC_ABBAyCdc20_2	0.1389
p.R359H	TCGA-CD-A4MG	STAD	TCGA	RTRVFLE	LIG_APCC_ABBAyCdc20_2	0.1389
p.R359H	DO48009	STAD	ICGC	RTRVFLE	LIG_APCC_ABBAyCdc20_2	0.1389
p.R359H	DO43747	UCEC	ICGC	RTRVFLE	LIG_APCC_ABBAyCdc20_2	0.1389
p.R359C	TCGA-D1-A17Q	UCEC	TCGA	RTRVFLE	LIG_APCC_ABBAyCdc20_2	0.1389
p.R359C	DO41903	UCEC	ICGC	RTRVFLE	LIG_APCC_ABBAyCdc20_2	0.1389
p.R357Q	TCGA-D7-8579	STAD	TCGA	RTRVFLE	LIG_APCC_ABBAyCdc20_2	0.1944
p.R357Q	DO47985	STAD	ICGC	RTRVFLE	LIG_APCC_ABBAyCdc20_2	0.1944
p.G345C	TCGA-VQ-A8P2	STAD	TCGA	RTRVFLE	LIG_APCC_ABBAyCdc20_2	0.3056
p.G345C	DO51761	STAD	ICGC	RTRVFLE	LIG_APCC_ABBAyCdc20_2	0.3056
p.T362N	DO229019	LICA	ICGC	RTRVFLE	LIG_APCC_ABBAyCdc20_2	0.0556
p.Q353K	DO229035	LICA	ICGC	RTRVFLE	LIG_APCC_ABBAyCdc20_2	0.3056
p.T362A	ACH-001610	Brain Cancer	CCLE	RTRVFLE	LIG_APCC_ABBAyCdc20_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y252	E3 ubiquitin-protein ligase RNF6	LIG_APCC_ABBAyCdc20_2	346:352	RTRVFLE	APC,CDC20,FZR1	0.9671	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons