DegronMD - Q9Y2E6(DTX4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D158N	TCGA-AJ-A5DW	UCEC	TCGA	VRRRLDLIY	DEG_APCC_DBOX_1	153:161	Mutation altering degron motif	0.5821
p.D158N	SIDM01483	Melanoma	GDSC	VRRRLDLIY	DEG_APCC_DBOX_1	153:161	Mutation altering degron motif	0.5821
p.D158N	SIDM00518	Mesothelioma	GDSC	VRRRLDLIY	DEG_APCC_DBOX_1	153:161	Mutation altering degron motif	0.5821
p.D158N	ACH-000582	Skin Cancer	CCLE	VRRRLDLIY	DEG_APCC_DBOX_1	153:161	Mutation altering degron motif	0.5821
p.D158N	ACH-002136	Lung Cancer	CCLE	VRRRLDLIY	DEG_APCC_DBOX_1	153:161	Mutation altering degron motif	0.5821
p.D158N	COLO-741	large intestine	COSMIC	VRRRLDLIY	DEG_APCC_DBOX_1	153:161	Mutation altering degron motif	0.5821
p.D158N	H290	pleura	COSMIC	VRRRLDLIY	DEG_APCC_DBOX_1	153:161	Mutation altering degron motif	0.5821
p.R154C	TCGA-B6-A0RS	BRCA	TCGA	VRRRLDLIY	DEG_APCC_DBOX_1	153:161	Mutation altering degron motif	0.8301
p.R156H	TCGA-DI-A1BU	UCEC	TCGA	VRRRLDLIY	DEG_APCC_DBOX_1	153:161	Mutation altering degron motif	0.7133
p.V153I	TCGA-IN-7806	STAD	TCGA	VRRRLDLIY	DEG_APCC_DBOX_1	153:161	Mutation altering degron motif	0.5965
p.R154H	TCGA-NH-A5IV	COAD	TCGA	VRRRLDLIY	DEG_APCC_DBOX_1	153:161	Mutation altering degron motif	0.8244
p.A147T	DO8722	COAD	ICGC	VRRRLDLIY	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.1667
p.A147T	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	VRRRLDLIY	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.1667
p.A156T	DO233168	GACA	ICGC	VRRRLDLIY	DEG_APCC_DBOX_1	153:161	Mutation altering degron motif	0.7139
p.S149L	DO13893	GBM	ICGC	VRRRLDLIY	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.2222
p.G162V	DO228978	LICA	ICGC	VRRRLDLIY	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.3056
p.R154I	DO229029	LICA	ICGC	VRRRLDLIY	DEG_APCC_DBOX_1	153:161	Mutation altering degron motif	0.8102
p.S158I	DO229008	LICA	ICGC	VRRRLDLIY	DEG_APCC_DBOX_1	153:161	Mutation altering degron motif	0.7341
p.P171L	DO220886	MELA	ICGC	VRRRLDLIY	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.0556
p.G166D	DO41584	UCEC	ICGC	VRRRLDLIY	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.1944
p.G166R	SIDM01218	Other Solid Cancers	GDSC	VRRRLDLIY	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.1944
p.G166R	ACH-001530	Endometrial/Uterine Cancer	CCLE	VRRRLDLIY	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.1944
p.G166R	JEG-3	placenta	COSMIC	VRRRLDLIY	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.1944
p.R151H	SIDM00217	Colorectal Carcinoma	GDSC	VRRRLDLIY	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.2778
p.R151H	ACH-000999	Colon/Colorectal Cancer	CCLE	VRRRLDLIY	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.2778
p.R151H	SNU-1040	large intestine	COSMIC	VRRRLDLIY	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.2778
p.R151C	SIDM00213	Thyroid Gland Carcinoma	GDSC	VRRRLDLIY	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.2778
p.R151C	ACH-000903	Thyroid Cancer	CCLE	VRRRLDLIY	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.2778
p.R151C	FTC-133	thyroid	COSMIC	VRRRLDLIY	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.2778
p.L168S	NCI-H650	lung	COSMIC	VRRRLDLIY	DEG_APCC_DBOX_1	153:161	Mutation rewiring degron network	0.1389
p.S158N	Mewo	skin	COSMIC	VRRRLDLIY	DEG_APCC_DBOX_1	153:161	Mutation altering degron motif	0.7069

Kaplan plot for DTX4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DTX4

UniProt ID: Q9Y2E6

Entrez ID: 23220

Protein name: E3 ubiquitin-protein ligase DTX4 (EC 2.3.2.27) (Protein deltex-4) (Deltex4) (RING finger protein 155) (RING-type E3 ubiquitin transferase DTX4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DTX4 in