DegronMD

Uniprot ID: Q9Y2E6

Source protein: E3 ubiquitin-protein ligase DTX4

Source gene: DTX4

Class: DEG_APCC_DBOX_1

Location: 153:161

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8505

ASA_SCORE: 99.0556

COIL: 0.5513

CONS_SCORE: 0.4611

DSS_SCORE: 0.4006

HELIX: 0.0349

FCONS_SCORE: 1.0947

RIG_SCORE: 0.8642

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D158N	TCGA-AJ-A5DW	UCEC	TCGA	VRRRLDLIY	DEG_APCC_DBOX_1	0.5821
p.D158N	SIDM01483	Melanoma	GDSC	VRRRLDLIY	DEG_APCC_DBOX_1	0.5821
p.D158N	SIDM00518	Mesothelioma	GDSC	VRRRLDLIY	DEG_APCC_DBOX_1	0.5821
p.D158N	ACH-000582	Skin Cancer	CCLE	VRRRLDLIY	DEG_APCC_DBOX_1	0.5821
p.D158N	ACH-002136	Lung Cancer	CCLE	VRRRLDLIY	DEG_APCC_DBOX_1	0.5821
p.D158N	COLO-741	large_intestine	COSMIC	VRRRLDLIY	DEG_APCC_DBOX_1	0.5821
p.D158N	H290	pleura	COSMIC	VRRRLDLIY	DEG_APCC_DBOX_1	0.5821
p.R154C	TCGA-B6-A0RS	BRCA	TCGA	VRRRLDLIY	DEG_APCC_DBOX_1	0.8301
p.R156H	TCGA-DI-A1BU	UCEC	TCGA	VRRRLDLIY	DEG_APCC_DBOX_1	0.7133
p.V153I	TCGA-IN-7806	STAD	TCGA	VRRRLDLIY	DEG_APCC_DBOX_1	0.5965
p.R154H	TCGA-NH-A5IV	COAD	TCGA	VRRRLDLIY	DEG_APCC_DBOX_1	0.8244
p.A147T	DO8722	COAD	ICGC	VRRRLDLIY	DEG_APCC_DBOX_1	0.1667
p.A147T	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	VRRRLDLIY	DEG_APCC_DBOX_1	0.1667
p.A156T	DO233168	GACA	ICGC	VRRRLDLIY	DEG_APCC_DBOX_1	0.7139
p.S149L	DO13893	GBM	ICGC	VRRRLDLIY	DEG_APCC_DBOX_1	0.2222
p.G162V	DO228978	LICA	ICGC	VRRRLDLIY	DEG_APCC_DBOX_1	0.3056
p.R154I	DO229029	LICA	ICGC	VRRRLDLIY	DEG_APCC_DBOX_1	0.8102
p.S158I	DO229008	LICA	ICGC	VRRRLDLIY	DEG_APCC_DBOX_1	0.7341
p.P171L	DO220886	MELA	ICGC	VRRRLDLIY	DEG_APCC_DBOX_1	0.0556
p.G166D	DO41584	UCEC	ICGC	VRRRLDLIY	DEG_APCC_DBOX_1	0.1944
p.G166R	SIDM01218	Other Solid Cancers	GDSC	VRRRLDLIY	DEG_APCC_DBOX_1	0.1944
p.G166R	ACH-001530	Endometrial/Uterine Cancer	CCLE	VRRRLDLIY	DEG_APCC_DBOX_1	0.1944
p.G166R	JEG-3	placenta	COSMIC	VRRRLDLIY	DEG_APCC_DBOX_1	0.1944
p.R151H	SIDM00217	Colorectal Carcinoma	GDSC	VRRRLDLIY	DEG_APCC_DBOX_1	0.2778
p.R151H	ACH-000999	Colon/Colorectal Cancer	CCLE	VRRRLDLIY	DEG_APCC_DBOX_1	0.2778
p.R151H	SNU-1040	large_intestine	COSMIC	VRRRLDLIY	DEG_APCC_DBOX_1	0.2778
p.R151C	SIDM00213	Thyroid Gland Carcinoma	GDSC	VRRRLDLIY	DEG_APCC_DBOX_1	0.2778
p.R151C	ACH-000903	Thyroid Cancer	CCLE	VRRRLDLIY	DEG_APCC_DBOX_1	0.2778
p.R151C	FTC-133	thyroid	COSMIC	VRRRLDLIY	DEG_APCC_DBOX_1	0.2778
p.L168S	NCI-H650	lung	COSMIC	VRRRLDLIY	DEG_APCC_DBOX_1	0.1389
p.S158N	Mewo	skin	COSMIC	VRRRLDLIY	DEG_APCC_DBOX_1	0.7069

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VRRRLDLIY

Degron related mutations and impact score

Drug responses associated with DTX4 mutations

All proteins holding degron of VRRRLDLIY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2E6	E3 ubiquitin-protein ligase DTX4	DEG_APCC_DBOX_1	153:161	VRRRLDLIY	APC,CDC20,FZR1	0.8505	More...