DegronMD - Q9Y2H2(INPP5F)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V1055L	TCGA-13-0890	OV	TCGA	LHVTPSPS	DEG_SCF_FBW7_1	1053:1060	Mutation altering degron motif	0.5654
p.V1055L	DO28273	OV	ICGC	LHVTPSPS	DEG_SCF_FBW7_1	1053:1060	Mutation altering degron motif	0.5654
p.S1064N	TCGA-AP-A1DH	UCEC	TCGA	LHVTPSPS	DEG_SCF_FBW7_1	1053:1060	Mutation rewiring degron network	0.2222
p.S1064N	DO43995	UCEC	ICGC	LHVTPSPS	DEG_SCF_FBW7_1	1053:1060	Mutation rewiring degron network	0.2222
p.A1067T	TCGA-D1-A17M	UCEC	TCGA	LHVTPSPS	DEG_SCF_FBW7_1	1053:1060	Mutation rewiring degron network	0.1389
p.A1067T	DO43779	UCEC	ICGC	LHVTPSPS	DEG_SCF_FBW7_1	1053:1060	Mutation rewiring degron network	0.1389
p.S1065N	TCGA-DU-6392	LGG	TCGA	LHVTPSPS	DEG_SCF_FBW7_1	1053:1060	Mutation rewiring degron network	0.1944
p.S1065N	DO22237	LGG	ICGC	LHVTPSPS	DEG_SCF_FBW7_1	1053:1060	Mutation rewiring degron network	0.1944
p.S1060L	TCGA-EW-A1IX	BRCA	TCGA	LHVTPSPS	DEG_SCF_FBW7_1	1053:1060	Mutation altering degron motif	0.7667
p.S1060L	TCGA-S5-AA26	BLCA	TCGA	LHVTPSPS	DEG_SCF_FBW7_1	1053:1060	Mutation altering degron motif	0.7667
p.S1060L	DO51904	BLCA	ICGC	LHVTPSPS	DEG_SCF_FBW7_1	1053:1060	Mutation altering degron motif	0.7667
p.S1060L	DO6177	BRCA	ICGC	LHVTPSPS	DEG_SCF_FBW7_1	1053:1060	Mutation altering degron motif	0.7667
p.S1058P	SIDM00422	Hodgkin's Lymphoma	GDSC	LHVTPSPS	DEG_SCF_FBW7_1	1053:1060	Mutation altering degron motif	0.5641
p.S1058P	SIDM00389	B-Cell Non-Hodgkin's Lymphoma	GDSC	LHVTPSPS	DEG_SCF_FBW7_1	1053:1060	Mutation altering degron motif	0.5641
p.S1058P	SIDM01002	Breast Carcinoma	GDSC	LHVTPSPS	DEG_SCF_FBW7_1	1053:1060	Mutation altering degron motif	0.5641
p.S1058P	SIDM00263	Ewing's Sarcoma	GDSC	LHVTPSPS	DEG_SCF_FBW7_1	1053:1060	Mutation altering degron motif	0.5641
p.S1058P	SIDM00908	Non-Cancerous	GDSC	LHVTPSPS	DEG_SCF_FBW7_1	1053:1060	Mutation altering degron motif	0.5641
p.S1058P	SIDM00992	Thyroid Gland Carcinoma	GDSC	LHVTPSPS	DEG_SCF_FBW7_1	1053:1060	Mutation altering degron motif	0.5641
p.S1058P	SIDM00195	Ewing's Sarcoma	GDSC	LHVTPSPS	DEG_SCF_FBW7_1	1053:1060	Mutation altering degron motif	0.5641
p.S1058P	SIDM00510	Small Cell Lung Carcinoma	GDSC	LHVTPSPS	DEG_SCF_FBW7_1	1053:1060	Mutation altering degron motif	0.5641
p.S1058P	SIDM00429	B-Lymphoblastic Leukemia	GDSC	LHVTPSPS	DEG_SCF_FBW7_1	1053:1060	Mutation altering degron motif	0.5641
p.S1058P	SIDM00044	Head and Neck Carcinoma	GDSC	LHVTPSPS	DEG_SCF_FBW7_1	1053:1060	Mutation altering degron motif	0.5641
p.S1058P	SIDM00575	Glioma	GDSC	LHVTPSPS	DEG_SCF_FBW7_1	1053:1060	Mutation altering degron motif	0.5641
p.S1058P	SIDM01777	Pancreatic Carcinoma	GDSC	LHVTPSPS	DEG_SCF_FBW7_1	1053:1060	Mutation altering degron motif	0.5641
p.S1058P	ACH-000093	Pancreatic Cancer	CCLE	LHVTPSPS	DEG_SCF_FBW7_1	1053:1060	Mutation altering degron motif	0.5641
p.P1057T	SIDM00263	Ewing's Sarcoma	GDSC	LHVTPSPS	DEG_SCF_FBW7_1	1053:1060	Mutation altering degron motif	0.7031
p.P1057T	SIDM01777	Pancreatic Carcinoma	GDSC	LHVTPSPS	DEG_SCF_FBW7_1	1053:1060	Mutation altering degron motif	0.7031
p.P1057T	ACH-000093	Pancreatic Cancer	CCLE	LHVTPSPS	DEG_SCF_FBW7_1	1053:1060	Mutation altering degron motif	0.7031
p.P1057T	ACH-002106	Bone Cancer	CCLE	LHVTPSPS	DEG_SCF_FBW7_1	1053:1060	Mutation altering degron motif	0.7031
p.S1063G	SIDM00282	Colorectal Carcinoma	GDSC	LHVTPSPS	DEG_SCF_FBW7_1	1053:1060	Mutation rewiring degron network	0.25
p.S1063G	ACH-000998	Colon/Colorectal Cancer	CCLE	LHVTPSPS	DEG_SCF_FBW7_1	1053:1060	Mutation rewiring degron network	0.25
p.S1063G	CW-2	large intestine	COSMIC	LHVTPSPS	DEG_SCF_FBW7_1	1053:1060	Mutation rewiring degron network	0.25

Kaplan plot for INPP5F in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

INPP5F

UniProt ID: Q9Y2H2

Entrez ID: 22876

Protein name: Phosphatidylinositide phosphatase SAC2 (EC 3.1.3.25) (Inositol polyphosphate 5-phosphatase F) (Sac domain-containing inositol phosphatase 2) (Sac domain-containing phosphoinositide 4-phosphatase 2) (hSAC2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for INPP5F in