DegronMD

Uniprot ID: Q9Y2H2

Source protein: Phosphatidylinositide phosphatase SAC2

Source gene: INPP5F

Class: DEG_SCF_FBW7_1

Location: 1053:1060

E3 ligase: FBXW7

DEGRON score: 0.9906

ASA_SCORE: 80.7625

COIL: 0.8833

CONS_SCORE: 0.1564

DSS_SCORE: 0.5832

HELIX: 0.0506

FCONS_SCORE: 0.7644

RIG_SCORE: 0.6289

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1055L	TCGA-13-0890	OV	TCGA	LHVTPSPS	DEG_SCF_FBW7_1	0.5654
p.V1055L	DO28273	OV	ICGC	LHVTPSPS	DEG_SCF_FBW7_1	0.5654
p.S1064N	TCGA-AP-A1DH	UCEC	TCGA	LHVTPSPS	DEG_SCF_FBW7_1	0.2222
p.S1064N	DO43995	UCEC	ICGC	LHVTPSPS	DEG_SCF_FBW7_1	0.2222
p.A1067T	TCGA-D1-A17M	UCEC	TCGA	LHVTPSPS	DEG_SCF_FBW7_1	0.1389
p.A1067T	DO43779	UCEC	ICGC	LHVTPSPS	DEG_SCF_FBW7_1	0.1389
p.S1065N	TCGA-DU-6392	LGG	TCGA	LHVTPSPS	DEG_SCF_FBW7_1	0.1944
p.S1065N	DO22237	LGG	ICGC	LHVTPSPS	DEG_SCF_FBW7_1	0.1944
p.S1060L	TCGA-EW-A1IX	BRCA	TCGA	LHVTPSPS	DEG_SCF_FBW7_1	0.7667
p.S1060L	TCGA-S5-AA26	BLCA	TCGA	LHVTPSPS	DEG_SCF_FBW7_1	0.7667
p.S1060L	DO51904	BLCA	ICGC	LHVTPSPS	DEG_SCF_FBW7_1	0.7667
p.S1060L	DO6177	BRCA	ICGC	LHVTPSPS	DEG_SCF_FBW7_1	0.7667
p.S1058P	SIDM00422	Hodgkin's Lymphoma	GDSC	LHVTPSPS	DEG_SCF_FBW7_1	0.5641
p.S1058P	SIDM00389	B-Cell Non-Hodgkin's Lymphoma	GDSC	LHVTPSPS	DEG_SCF_FBW7_1	0.5641
p.S1058P	SIDM01002	Breast Carcinoma	GDSC	LHVTPSPS	DEG_SCF_FBW7_1	0.5641
p.S1058P	SIDM00263	Ewing's Sarcoma	GDSC	LHVTPSPS	DEG_SCF_FBW7_1	0.5641
p.S1058P	SIDM00908	Non-Cancerous	GDSC	LHVTPSPS	DEG_SCF_FBW7_1	0.5641
p.S1058P	SIDM00992	Thyroid Gland Carcinoma	GDSC	LHVTPSPS	DEG_SCF_FBW7_1	0.5641
p.S1058P	SIDM00195	Ewing's Sarcoma	GDSC	LHVTPSPS	DEG_SCF_FBW7_1	0.5641
p.S1058P	SIDM00510	Small Cell Lung Carcinoma	GDSC	LHVTPSPS	DEG_SCF_FBW7_1	0.5641
p.S1058P	SIDM00429	B-Lymphoblastic Leukemia	GDSC	LHVTPSPS	DEG_SCF_FBW7_1	0.5641
p.S1058P	SIDM00044	Head and Neck Carcinoma	GDSC	LHVTPSPS	DEG_SCF_FBW7_1	0.5641
p.S1058P	SIDM00575	Glioma	GDSC	LHVTPSPS	DEG_SCF_FBW7_1	0.5641
p.S1058P	SIDM01777	Pancreatic Carcinoma	GDSC	LHVTPSPS	DEG_SCF_FBW7_1	0.5641
p.S1058P	ACH-000093	Pancreatic Cancer	CCLE	LHVTPSPS	DEG_SCF_FBW7_1	0.5641
p.P1057T	SIDM00263	Ewing's Sarcoma	GDSC	LHVTPSPS	DEG_SCF_FBW7_1	0.7031
p.P1057T	SIDM01777	Pancreatic Carcinoma	GDSC	LHVTPSPS	DEG_SCF_FBW7_1	0.7031
p.P1057T	ACH-000093	Pancreatic Cancer	CCLE	LHVTPSPS	DEG_SCF_FBW7_1	0.7031
p.P1057T	ACH-002106	Bone Cancer	CCLE	LHVTPSPS	DEG_SCF_FBW7_1	0.7031
p.S1063G	SIDM00282	Colorectal Carcinoma	GDSC	LHVTPSPS	DEG_SCF_FBW7_1	0.25
p.S1063G	ACH-000998	Colon/Colorectal Cancer	CCLE	LHVTPSPS	DEG_SCF_FBW7_1	0.25
p.S1063G	CW-2	large_intestine	COSMIC	LHVTPSPS	DEG_SCF_FBW7_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LHVTPSPS

Degron related mutations and impact score

Drug responses associated with INPP5F mutations

All proteins holding degron of LHVTPSPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2H2	Phosphatidylinositide phosphatase SAC2	DEG_SCF_FBW7_1	1053:1060	LHVTPSPS	FBXW7	0.9906	More...