DegronMD - Q9Y2J0(RPH3A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G305R	TCGA-05-4417	LUAD	TCGA	PGTPGGS	DEG_SCF_FBW7_1	294:300	Mutation rewiring degron network	0.1944
p.G305R	DO23570	LUAD	ICGC	PGTPGGS	DEG_SCF_FBW7_1	294:300	Mutation rewiring degron network	0.1944
p.P302L	TCGA-28-1753	GBM	TCGA	PGTPGGS	DEG_SCF_FBW7_1	294:300	Mutation rewiring degron network	0.2778
p.P302L	DO11687	GBM	ICGC	PGTPGGS	DEG_SCF_FBW7_1	294:300	Mutation rewiring degron network	0.2778
p.P306T	TCGA-37-3792	LUSC	TCGA	PGTPGGS	DEG_SCF_FBW7_1	294:300	Mutation rewiring degron network	0.1667
p.P306T	DO27192	LUSC	ICGC	PGTPGGS	DEG_SCF_FBW7_1	294:300	Mutation rewiring degron network	0.1667
p.P288L	TCGA-4A-A93W	KIRP	TCGA	PGTPGGS	DEG_SCF_FBW7_1	294:300	Mutation rewiring degron network	0.1667
p.P288L	DO219688	KIRP	ICGC	PGTPGGS	DEG_SCF_FBW7_1	294:300	Mutation rewiring degron network	0.1667
p.S285N	DO222755	COCA	ICGC	PGTPGGS	DEG_SCF_FBW7_1	294:300	Mutation rewiring degron network	0.0833
p.Q293H	DO229016	COCA	ICGC	PGTPGGS	DEG_SCF_FBW7_1	294:300	Mutation rewiring degron network	0.3056
p.Q293H	DO229003	COCA	ICGC	PGTPGGS	DEG_SCF_FBW7_1	294:300	Mutation rewiring degron network	0.3056
p.Q293H	DO231075	LUSC	ICGC	PGTPGGS	DEG_SCF_FBW7_1	294:300	Mutation rewiring degron network	0.3056
p.G295W	DO229029	LICA	ICGC	PGTPGGS	DEG_SCF_FBW7_1	294:300	Mutation altering degron motif	0.6714
p.G298E	DO220886	MELA	ICGC	PGTPGGS	DEG_SCF_FBW7_1	294:300	Mutation altering degron motif	0.6087
p.P304L	SIDM01460	Glioma	GDSC	PGTPGGS	DEG_SCF_FBW7_1	294:300	Mutation rewiring degron network	0.2222
p.P304L	ACH-000592	Brain Cancer	CCLE	PGTPGGS	DEG_SCF_FBW7_1	294:300	Mutation rewiring degron network	0.2222
p.Q293K	ACH-000029	Lung Cancer	CCLE	PGTPGGS	DEG_SCF_FBW7_1	294:300	Mutation rewiring degron network	0.3056
p.G288W	22RV1	prostate	COSMIC	PGTPGGS	DEG_SCF_FBW7_1	294:300	Mutation rewiring degron network	0.1667
p.R299Q	HT-115	large intestine	COSMIC	PGTPGGS	DEG_SCF_FBW7_1	294:300	Mutation altering degron motif	0.7329
p.Y290H	SNU-1040	large intestine	COSMIC	PGTPGGS	DEG_SCF_FBW7_1	294:300	Mutation rewiring degron network	0.2222

Kaplan plot for RPH3A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RPH3A

UniProt ID: Q9Y2J0

Entrez ID: 22895

Protein name: Rabphilin-3A (Exophilin-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RPH3A in