DegronMD

Uniprot ID: Q9Y2J0

Source protein: Rabphilin-3A

Source gene: RPH3A

Class: DEG_SCF_FBW7_1

Location: 294:300

E3 ligase: FBXW7

DEGRON score: 0.9707

ASA_SCORE: 58.1

COIL: 0.9186

CONS_SCORE: 0.3373

DSS_SCORE: 0.9471

HELIX: 0.0271

FCONS_SCORE: 0.7776

RIG_SCORE: 0.3955

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G305R	TCGA-05-4417	LUAD	TCGA	PGTPGGS	DEG_SCF_FBW7_1	0.1944
p.G305R	DO23570	LUAD	ICGC	PGTPGGS	DEG_SCF_FBW7_1	0.1944
p.P302L	TCGA-28-1753	GBM	TCGA	PGTPGGS	DEG_SCF_FBW7_1	0.2778
p.P302L	DO11687	GBM	ICGC	PGTPGGS	DEG_SCF_FBW7_1	0.2778
p.P306T	TCGA-37-3792	LUSC	TCGA	PGTPGGS	DEG_SCF_FBW7_1	0.1667
p.P306T	DO27192	LUSC	ICGC	PGTPGGS	DEG_SCF_FBW7_1	0.1667
p.P288L	TCGA-4A-A93W	KIRP	TCGA	PGTPGGS	DEG_SCF_FBW7_1	0.1667
p.P288L	DO219688	KIRP	ICGC	PGTPGGS	DEG_SCF_FBW7_1	0.1667
p.S285N	DO222755	COCA	ICGC	PGTPGGS	DEG_SCF_FBW7_1	0.0833
p.Q293H	DO229016	COCA	ICGC	PGTPGGS	DEG_SCF_FBW7_1	0.3056
p.Q293H	DO229003	COCA	ICGC	PGTPGGS	DEG_SCF_FBW7_1	0.3056
p.Q293H	DO231075	LUSC	ICGC	PGTPGGS	DEG_SCF_FBW7_1	0.3056
p.G295W	DO229029	LICA	ICGC	PGTPGGS	DEG_SCF_FBW7_1	0.6714
p.G298E	DO220886	MELA	ICGC	PGTPGGS	DEG_SCF_FBW7_1	0.6087
p.P304L	SIDM01460	Glioma	GDSC	PGTPGGS	DEG_SCF_FBW7_1	0.2222
p.P304L	ACH-000592	Brain Cancer	CCLE	PGTPGGS	DEG_SCF_FBW7_1	0.2222
p.Q293K	ACH-000029	Lung Cancer	CCLE	PGTPGGS	DEG_SCF_FBW7_1	0.3056
p.G288W	22RV1	prostate	COSMIC	PGTPGGS	DEG_SCF_FBW7_1	0.1667
p.R299Q	HT-115	large_intestine	COSMIC	PGTPGGS	DEG_SCF_FBW7_1	0.7329
p.Y290H	SNU-1040	large_intestine	COSMIC	PGTPGGS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2J0	Rabphilin-3A	DEG_SCF_FBW7_1	294:300	PGTPGGS	FBXW7	0.9707	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons