DegronMD - Q9Y2K1(ZBTB1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q134L	TCGA-A3-3378	KIRC	TCGA	VRMYED	LIG_APCC_ABBA_1	142:147	Mutation rewiring degron network	0.1111
p.M144R	DO218796	BRCA	ICGC	VRMYED	LIG_APCC_ABBA_1	142:147	Mutation altering degron motif	0.8632
p.R151Q	DO233272	GACA	ICGC	VRMYED	LIG_APCC_ABBA_1	142:147	Mutation rewiring degron network	0.2222
p.I139M	SIDM02021	Esophageal Carcinoma	GDSC	VRMYED	LIG_APCC_ABBA_1	142:147	Mutation rewiring degron network	0.25
p.M138I	SIDM00193	Colorectal Carcinoma	GDSC	VRMYED	LIG_APCC_ABBA_1	142:147	Mutation rewiring degron network	0.2222
p.M138I	ACH-000991	Colon/Colorectal Cancer	CCLE	VRMYED	LIG_APCC_ABBA_1	142:147	Mutation rewiring degron network	0.2222
p.M138I	SNU-81	large intestine	COSMIC	VRMYED	LIG_APCC_ABBA_1	142:147	Mutation rewiring degron network	0.2222
p.V142I	SIDM00896	B-Cell Non-Hodgkin's Lymphoma	GDSC	VRMYED	LIG_APCC_ABBA_1	142:147	Mutation altering degron motif	0.5965
p.V142I	ACH-002214	Lymphoma	CCLE	VRMYED	LIG_APCC_ABBA_1	142:147	Mutation altering degron motif	0.5965
p.V142I	BC-1	haematopoietic and lymphoid tissue	COSMIC	VRMYED	LIG_APCC_ABBA_1	142:147	Mutation altering degron motif	0.5965

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons