DegronMD

Uniprot ID: Q9Y2K1

Source protein: Zinc finger and BTB domain-containing protein 1

Source gene: ZBTB1

Class: LIG_APCC_ABBA_1

Location: 142:147

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9279

ASA_SCORE: 111.4

COIL: 0.5935

CONS_SCORE: 0.703

DSS_SCORE: 0.4205

HELIX: 0.0675

FCONS_SCORE: 1.2809

RIG_SCORE: 0.8309

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q134L	TCGA-A3-3378	KIRC	TCGA	VRMYED	LIG_APCC_ABBA_1	0.1111
p.M144R	DO218796	BRCA	ICGC	VRMYED	LIG_APCC_ABBA_1	0.8632
p.R151Q	DO233272	GACA	ICGC	VRMYED	LIG_APCC_ABBA_1	0.2222
p.I139M	SIDM02021	Esophageal Carcinoma	GDSC	VRMYED	LIG_APCC_ABBA_1	0.25
p.M138I	SIDM00193	Colorectal Carcinoma	GDSC	VRMYED	LIG_APCC_ABBA_1	0.2222
p.M138I	ACH-000991	Colon/Colorectal Cancer	CCLE	VRMYED	LIG_APCC_ABBA_1	0.2222
p.M138I	SNU-81	large_intestine	COSMIC	VRMYED	LIG_APCC_ABBA_1	0.2222
p.V142I	SIDM00896	B-Cell Non-Hodgkin's Lymphoma	GDSC	VRMYED	LIG_APCC_ABBA_1	0.5965
p.V142I	ACH-002214	Lymphoma	CCLE	VRMYED	LIG_APCC_ABBA_1	0.5965
p.V142I	BC-1	haematopoietic_and_lymphoid_tissue	COSMIC	VRMYED	LIG_APCC_ABBA_1	0.5965

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2K1	Zinc finger and BTB domain-containing protein 1	LIG_APCC_ABBA_1	142:147	VRMYED	APC,CDC20,FZR1	0.9279	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons