KDM2A
UniProt ID: Q9Y2K7
Entrez ID: 22992
Protein name: Lysine-specific demethylase 2A (EC 1.14.11.27) (CXXC-type zinc finger protein 8) (F-box and leucine-rich repeat protein 11) (F-box protein FBL7) (F-box protein Lilina) (F-box/LRR-repeat protein 11) (JmjC domain-containing histone demethylation protein 1A) ([Histone-H3]-lysine-36 demethylase 1A)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to ...
FUNCTION: Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis. Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-ARNTL/BMAL1 heterodimer and RORA in a catalytically-independent manner (PubMed:26037310). {ECO:0000269|PubMed:16362057, ECO:0000269|PubMed:19001877, ECO:0000269|PubMed:26037310, ECO:0000269|PubMed:28262558}.
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GO - Biological processes (BP):
chromatin organization [GO:0006325]; circadian regulation of gene expression [GO:0032922]; double-strand break repair via nonhomologous end joining [GO:0006303]; histone H3-K36 demethylation [GO:0070544]; negative regulation of transcription by competitive promoter binding [GO:0010944]; protein deme...
chromatin organization [GO:0006325]; circadian regulation of gene expression [GO:0032922]; double-strand break repair via nonhomologous end joining [GO:0006303]; histone H3-K36 demethylation [GO:0070544]; negative regulation of transcription by competitive promoter binding [GO:0010944]; protein demethylation [GO:0006482]; regulation of circadian rhythm [GO:0042752]; regulation of transcription by RNA polymerase II [GO:0006357]
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GO - Molecular function (MF):
histone demethylase activity [GO:0032452]; histone H3-di/monomethyl-lysine-36 demethylase activity [GO:0140680]; histone H3-methyl-lysine-36 demethylase activity [GO:0051864]; transcription coregulator activity [GO:0003712]; unmethylated CpG binding [GO:0045322]; zinc ion binding [GO:0008270]...
histone demethylase activity [GO:0032452]; histone H3-di/monomethyl-lysine-36 demethylase activity [GO:0140680]; histone H3-methyl-lysine-36 demethylase activity [GO:0051864]; transcription coregulator activity [GO:0003712]; unmethylated CpG binding [GO:0045322]; zinc ion binding [GO:0008270]
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GO - Cellular component (CC):
nucleoplasm [GO:0005654]...
nucleoplasm [GO:0005654]
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KDM2A
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Kaplan plot for KDM2A in
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*NOTE: the Kaplan plots were collected from OncoLnc