DegronMD

Uniprot ID: Q9Y2K7

Source protein: Lysine-specific demethylase 2A

Source gene: KDM2A

Class: DEG_APCC_KENBOX_2

Location: 775:779

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9666

ASA_SCORE: 114.72

COIL: 0.6642

CONS_SCORE: 0.3101

DSS_SCORE: 0.6618

HELIX: 0.331

FCONS_SCORE: 1.0761

RIG_SCORE: 0.6652

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R774W	TCGA-CF-A1HS	BLCA	TCGA	EKENN	DEG_APCC_KENBOX_2	0.3056
p.E777K	DO1071	BRCA	ICGC	EKENN	DEG_APCC_KENBOX_2	0.7022
p.E788G	DO233270	GACA	ICGC	EKENN	DEG_APCC_KENBOX_2	0.0833
p.P780L	DO222843	MELA	ICGC	EKENN	DEG_APCC_KENBOX_2	0.3056
p.R770H	DO232761	PBCA	ICGC	EKENN	DEG_APCC_KENBOX_2	0.1944
p.R770H	SIDM01451	Pancreatic Carcinoma	GDSC	EKENN	DEG_APCC_KENBOX_2	0.1944
p.R770H	ACH-000933	Pancreatic Cancer	CCLE	EKENN	DEG_APCC_KENBOX_2	0.1944
p.P780S	SIDM00429	B-Lymphoblastic Leukemia	GDSC	EKENN	DEG_APCC_KENBOX_2	0.3056
p.P780S	ACH-000938	Leukemia	CCLE	EKENN	DEG_APCC_KENBOX_2	0.3056
p.P780S	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	EKENN	DEG_APCC_KENBOX_2	0.3056
p.G782C	ACH-001390	Breast Cancer	CCLE	EKENN	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A2RUB6	Coiled-coil domain-containing protein 66	DEG_APCC_KENBOX_2	671:675	EKENN	APC,CDC20,FZR1	0.9644	More...
Q6P0N0	Mis18-binding protein 1	DEG_APCC_KENBOX_2	166:170	EKENN	APC,CDC20,FZR1	0.8428	More...
Q9Y2K7	Lysine-specific demethylase 2A	DEG_APCC_KENBOX_2	775:779	EKENN	APC,CDC20,FZR1	0.9666	More...
Q6ZMT9	Death domain-containing protein 1	DEG_APCC_KENBOX_2	65:69	EKENN	APC,CDC20,FZR1	0.9955	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons