DegronMD - A2RUB6(CCDC66)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S372R	TCGA-06-5416	GBM	TCGA	RWAMHFD	LIG_APCC_ABBAyCdc20_2	362:368	Mutation rewiring degron network	0.2222
p.S372R	DO10880	GBM	ICGC	RWAMHFD	LIG_APCC_ABBAyCdc20_2	362:368	Mutation rewiring degron network	0.2222
p.N674S	TCGA-A5-A1OF	UCEC	TCGA	EKENN	DEG_APCC_KENBOX_2	671:675	Mutation altering degron motif	0.7069
p.N674S	DO42568	UCEC	ICGC	EKENN	DEG_APCC_KENBOX_2	671:675	Mutation altering degron motif	0.7069
p.R676Q	TCGA-A6-5661	COAD	TCGA	EKENN	DEG_APCC_KENBOX_2	671:675	Mutation rewiring degron network	0.3056
p.R676Q	DO8634	COAD	ICGC	EKENN	DEG_APCC_KENBOX_2	671:675	Mutation rewiring degron network	0.3056
p.I352S	TCGA-B5-A1MR	UCEC	TCGA	RWAMHFD	LIG_APCC_ABBAyCdc20_2	362:368	Mutation rewiring degron network	0.0556
p.I352S	TCGA-E6-A1M0	UCEC	TCGA	RWAMHFD	LIG_APCC_ABBAyCdc20_2	362:368	Mutation rewiring degron network	0.0556
p.I352S	DO43682	UCEC	ICGC	RWAMHFD	LIG_APCC_ABBAyCdc20_2	362:368	Mutation rewiring degron network	0.0556
p.I352S	DO41758	UCEC	ICGC	RWAMHFD	LIG_APCC_ABBAyCdc20_2	362:368	Mutation rewiring degron network	0.0556
p.P374T	TCGA-E9-A1NE	BRCA	TCGA	RWAMHFD	LIG_APCC_ABBAyCdc20_2	362:368	Mutation rewiring degron network	0.1667
p.P374T	DO1436	BRCA	ICGC	RWAMHFD	LIG_APCC_ABBAyCdc20_2	362:368	Mutation rewiring degron network	0.1667
p.E358D	TCGA-ER-A19Q	SKCM	TCGA	RWAMHFD	LIG_APCC_ABBAyCdc20_2	362:368	Mutation rewiring degron network	0.2222
p.E358D	DO47497	SKCM	ICGC	RWAMHFD	LIG_APCC_ABBAyCdc20_2	362:368	Mutation rewiring degron network	0.2222
p.D368N	TCGA-WE-A8K6	SKCM	TCGA	RWAMHFD	LIG_APCC_ABBAyCdc20_2	362:368	Mutation altering degron motif	0.6932
p.D368N	DO51283	SKCM	ICGC	RWAMHFD	LIG_APCC_ABBAyCdc20_2	362:368	Mutation altering degron motif	0.6932
p.R676L	DO8858	COAD	ICGC	EKENN	DEG_APCC_KENBOX_2	671:675	Mutation rewiring degron network	0.3056
p.G357V	DO229019	LICA	ICGC	RWAMHFD	LIG_APCC_ABBAyCdc20_2	362:368	Mutation rewiring degron network	0.1944
p.D361Y	DO229044	LICA	ICGC	RWAMHFD	LIG_APCC_ABBAyCdc20_2	362:368	Mutation rewiring degron network	0.3056
p.C677F	DO46424	OV	ICGC	EKENN	DEG_APCC_KENBOX_2	671:675	Mutation rewiring degron network	0.2778
p.A364E	DO51180	PAEN	ICGC	RWAMHFD	LIG_APCC_ABBAyCdc20_2	362:368	Mutation altering degron motif	0.659
p.E671Q	SIDM00884	Breast Carcinoma	GDSC	EKENN	DEG_APCC_KENBOX_2	671:675	Mutation altering degron motif	0.5633
p.E671Q	SIDM01659	Kidney Carcinoma	GDSC	EKENN	DEG_APCC_KENBOX_2	671:675	Mutation altering degron motif	0.5633
p.E671Q	ACH-000699	Breast Cancer	CCLE	EKENN	DEG_APCC_KENBOX_2	671:675	Mutation altering degron motif	0.5633
p.E671Q	HCC1395	breast	COSMIC	EKENN	DEG_APCC_KENBOX_2	671:675	Mutation altering degron motif	0.5633
p.M365V	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	RWAMHFD	LIG_APCC_ABBAyCdc20_2	362:368	Mutation altering degron motif	0.6097
p.M365V	SIDM01173	Rhabdomyosarcoma	GDSC	RWAMHFD	LIG_APCC_ABBAyCdc20_2	362:368	Mutation altering degron motif	0.6097
p.R676W	SIDM00532	Glioma	GDSC	EKENN	DEG_APCC_KENBOX_2	671:675	Mutation rewiring degron network	0.3056
p.R676W	ACH-001125	Brain Cancer	CCLE	EKENN	DEG_APCC_KENBOX_2	671:675	Mutation rewiring degron network	0.3056
p.R676W	MOG-G-CCM	central nervous system	COSMIC	EKENN	DEG_APCC_KENBOX_2	671:675	Mutation rewiring degron network	0.3056
p.N675S	ACH-000901	Lung Cancer	CCLE	EKENN	DEG_APCC_KENBOX_2	671:675	Mutation altering degron motif	0.5958
p.D368G	ACH-000993	Endometrial/Uterine Cancer	CCLE	RWAMHFD	LIG_APCC_ABBAyCdc20_2	362:368	Mutation altering degron motif	0.7198
p.E366K	NCI-H2110	lung	COSMIC	RWAMHFD	LIG_APCC_ABBAyCdc20_2	362:368	Mutation altering degron motif	0.7022

Kaplan plot for CCDC66 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCDC66

UniProt ID: A2RUB6

Entrez ID: 285331

Protein name: Coiled-coil domain-containing protein 66

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for CCDC66 in