DegronMD

Uniprot ID: A2RUB6

Source protein: Coiled-coil domain-containing protein 66

Source gene: CCDC66

Class: LIG_APCC_ABBAyCdc20_2

Location: 362:368

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8802

ASA_SCORE: 84.7286

COIL: 0.4014

CONS_SCORE: 0.5309

DSS_SCORE: 0.4122

HELIX: 0.557

FCONS_SCORE: 1.1624

RIG_SCORE: 0.7834

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S372R	TCGA-06-5416	GBM	TCGA	RWAMHFD	LIG_APCC_ABBAyCdc20_2	0.2222
p.S372R	DO10880	GBM	ICGC	RWAMHFD	LIG_APCC_ABBAyCdc20_2	0.2222
p.I352S	TCGA-B5-A1MR	UCEC	TCGA	RWAMHFD	LIG_APCC_ABBAyCdc20_2	0.0556
p.I352S	TCGA-E6-A1M0	UCEC	TCGA	RWAMHFD	LIG_APCC_ABBAyCdc20_2	0.0556
p.I352S	DO43682	UCEC	ICGC	RWAMHFD	LIG_APCC_ABBAyCdc20_2	0.0556
p.I352S	DO41758	UCEC	ICGC	RWAMHFD	LIG_APCC_ABBAyCdc20_2	0.0556
p.P374T	TCGA-E9-A1NE	BRCA	TCGA	RWAMHFD	LIG_APCC_ABBAyCdc20_2	0.1667
p.P374T	DO1436	BRCA	ICGC	RWAMHFD	LIG_APCC_ABBAyCdc20_2	0.1667
p.E358D	TCGA-ER-A19Q	SKCM	TCGA	RWAMHFD	LIG_APCC_ABBAyCdc20_2	0.2222
p.E358D	DO47497	SKCM	ICGC	RWAMHFD	LIG_APCC_ABBAyCdc20_2	0.2222
p.D368N	TCGA-WE-A8K6	SKCM	TCGA	RWAMHFD	LIG_APCC_ABBAyCdc20_2	0.6932
p.D368N	DO51283	SKCM	ICGC	RWAMHFD	LIG_APCC_ABBAyCdc20_2	0.6932
p.G357V	DO229019	LICA	ICGC	RWAMHFD	LIG_APCC_ABBAyCdc20_2	0.1944
p.D361Y	DO229044	LICA	ICGC	RWAMHFD	LIG_APCC_ABBAyCdc20_2	0.3056
p.A364E	DO51180	PAEN	ICGC	RWAMHFD	LIG_APCC_ABBAyCdc20_2	0.659
p.M365V	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	RWAMHFD	LIG_APCC_ABBAyCdc20_2	0.6097
p.M365V	SIDM01173	Rhabdomyosarcoma	GDSC	RWAMHFD	LIG_APCC_ABBAyCdc20_2	0.6097
p.D368G	ACH-000993	Endometrial/Uterine Cancer	CCLE	RWAMHFD	LIG_APCC_ABBAyCdc20_2	0.7198
p.E366K	NCI-H2110	lung	COSMIC	RWAMHFD	LIG_APCC_ABBAyCdc20_2	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A2RUB6	Coiled-coil domain-containing protein 66	LIG_APCC_ABBAyCdc20_2	362:368	RWAMHFD	APC,CDC20,FZR1	0.8802	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons