DegronMD

Uniprot ID: A2RUB6

Source protein: Coiled-coil domain-containing protein 66

Source gene: CCDC66

Class: DEG_APCC_KENBOX_2

Location: 671:675

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9644

ASA_SCORE: 122.7

COIL: 0.588

CONS_SCORE: 0.3913

DSS_SCORE: 0.4889

HELIX: 0.3992

FCONS_SCORE: 1.026

RIG_SCORE: 0.7085

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N674S	TCGA-A5-A1OF	UCEC	TCGA	EKENN	DEG_APCC_KENBOX_2	0.7069
p.N674S	DO42568	UCEC	ICGC	EKENN	DEG_APCC_KENBOX_2	0.7069
p.R676Q	TCGA-A6-5661	COAD	TCGA	EKENN	DEG_APCC_KENBOX_2	0.3056
p.R676Q	DO8634	COAD	ICGC	EKENN	DEG_APCC_KENBOX_2	0.3056
p.R676L	DO8858	COAD	ICGC	EKENN	DEG_APCC_KENBOX_2	0.3056
p.C677F	DO46424	OV	ICGC	EKENN	DEG_APCC_KENBOX_2	0.2778
p.E671Q	SIDM00884	Breast Carcinoma	GDSC	EKENN	DEG_APCC_KENBOX_2	0.5633
p.E671Q	SIDM01659	Kidney Carcinoma	GDSC	EKENN	DEG_APCC_KENBOX_2	0.5633
p.E671Q	ACH-000699	Breast Cancer	CCLE	EKENN	DEG_APCC_KENBOX_2	0.5633
p.E671Q	HCC1395	breast	COSMIC	EKENN	DEG_APCC_KENBOX_2	0.5633
p.R676W	SIDM00532	Glioma	GDSC	EKENN	DEG_APCC_KENBOX_2	0.3056
p.R676W	ACH-001125	Brain Cancer	CCLE	EKENN	DEG_APCC_KENBOX_2	0.3056
p.R676W	MOG-G-CCM	central_nervous_system	COSMIC	EKENN	DEG_APCC_KENBOX_2	0.3056
p.N675S	ACH-000901	Lung Cancer	CCLE	EKENN	DEG_APCC_KENBOX_2	0.5958

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A2RUB6	Coiled-coil domain-containing protein 66	DEG_APCC_KENBOX_2	671:675	EKENN	APC,CDC20,FZR1	0.9644	More...
Q6P0N0	Mis18-binding protein 1	DEG_APCC_KENBOX_2	166:170	EKENN	APC,CDC20,FZR1	0.8428	More...
Q9Y2K7	Lysine-specific demethylase 2A	DEG_APCC_KENBOX_2	775:779	EKENN	APC,CDC20,FZR1	0.9666	More...
Q6ZMT9	Death domain-containing protein 1	DEG_APCC_KENBOX_2	65:69	EKENN	APC,CDC20,FZR1	0.9955	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons