DegronMD - Q6ZMT9(DTHD1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K56N	DO224965	BRCA	ICGC	EKENN	DEG_APCC_KENBOX_2	65:69	Mutation substituting flanking lysine	0.1944
p.K56N	DO227820	BRCA	ICGC	EKENN	DEG_APCC_KENBOX_2	65:69	Mutation substituting flanking lysine	0.1944
p.K56N	DO229050	LICA	ICGC	EKENN	DEG_APCC_KENBOX_2	65:69	Mutation substituting flanking lysine	0.1944
p.G26R	DO229010	COCA	ICGC	ARGELNVIE	DEG_APCC_DBOX_1	24:32	Mutation altering degron motif	0.6457
p.G26R	DO229016	COCA	ICGC	ARGELNVIE	DEG_APCC_DBOX_1	24:32	Mutation altering degron motif	0.6457
p.V14D	DO229010	COCA	ICGC	ARGELNVIE	DEG_APCC_DBOX_1	24:32	Mutation rewiring degron network	0.0556
p.V14D	DO229013	COCA	ICGC	ARGELNVIE	DEG_APCC_DBOX_1	24:32	Mutation rewiring degron network	0.0556
p.V14D	DO229016	COCA	ICGC	ARGELNVIE	DEG_APCC_DBOX_1	24:32	Mutation rewiring degron network	0.0556
p.V14D	DO229003	COCA	ICGC	ARGELNVIE	DEG_APCC_DBOX_1	24:32	Mutation rewiring degron network	0.0556
p.V14D	DO229005	COCA	ICGC	ARGELNVIE	DEG_APCC_DBOX_1	24:32	Mutation rewiring degron network	0.0556
p.V14I	DO225404	LAML	ICGC	ARGELNVIE	DEG_APCC_DBOX_1	24:32	Mutation rewiring degron network	0.0556
p.V14I	KYSE-140	oesophagus	COSMIC	ARGELNVIE	DEG_APCC_DBOX_1	24:32	Mutation rewiring degron network	0.0556
p.V14I	SNU-1040	large intestine	COSMIC	ARGELNVIE	DEG_APCC_DBOX_1	24:32	Mutation rewiring degron network	0.0556
p.V14I	NEC8	testis	COSMIC	ARGELNVIE	DEG_APCC_DBOX_1	24:32	Mutation rewiring degron network	0.0556
p.V14I	NUGC-4	stomach	COSMIC	ARGELNVIE	DEG_APCC_DBOX_1	24:32	Mutation rewiring degron network	0.0556
p.V14I	TGBC24TKB	biliary tract	COSMIC	ARGELNVIE	DEG_APCC_DBOX_1	24:32	Mutation rewiring degron network	0.0556
p.V14F	DO228948	LICA	ICGC	ARGELNVIE	DEG_APCC_DBOX_1	24:32	Mutation rewiring degron network	0.0556
p.E32K	DO222702	MELA	ICGC	ARGELNVIE	DEG_APCC_DBOX_1	24:32	Mutation altering degron motif	0.591
p.H20Q	DO38404	STAD	ICGC	ARGELNVIE	DEG_APCC_DBOX_1	24:32	Mutation rewiring degron network	0.2222
p.N39H	DO43186	UCEC	ICGC	ARGELNVIE	DEG_APCC_DBOX_1	24:32	Mutation rewiring degron network	0.1389
p.S77Y	ACH-001028	Rhabdoid	CCLE	EKENN	DEG_APCC_KENBOX_2	65:69	Mutation rewiring degron network	0.1111
p.I37K	ACH-001715	Bone Cancer	CCLE	ARGELNVIE	DEG_APCC_DBOX_1	24:32	Mutation rewiring degron network	0.1944
p.I37K	CAL-72	bone	COSMIC	ARGELNVIE	DEG_APCC_DBOX_1	24:32	Mutation rewiring degron network	0.1944
p.L30Q	HARA	lung	COSMIC	ARGELNVIE	DEG_APCC_DBOX_1	24:32	Mutation altering degron motif	0.7765
p.C61F	NCI-H2227	lung	COSMIC	EKENN	DEG_APCC_KENBOX_2	65:69	Mutation rewiring degron network	0.2222
p.L30P	EW-7	bone	COSMIC	ARGELNVIE	DEG_APCC_DBOX_1	24:32	Mutation altering degron motif	0.7582

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DTHD1

UniProt ID: Q6ZMT9

Entrez ID: 401124

Protein name: Death domain-containing protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DTHD1 in