DegronMD

Uniprot ID: Q6ZMT9

Source protein: Death domain-containing protein 1

Source gene: DTHD1

Class: DEG_APCC_KENBOX_2

Location: 65:69

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9955

ASA_SCORE: 118.52

COIL: 0.7726

CONS_SCORE: 0.3853

DSS_SCORE: 0.6103

HELIX: 0.1898

FCONS_SCORE: 1.3921

RIG_SCORE: 0.7106

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K56N	DO224965	BRCA	ICGC	EKENN	DEG_APCC_KENBOX_2	0.1944
p.K56N	DO227820	BRCA	ICGC	EKENN	DEG_APCC_KENBOX_2	0.1944
p.K56N	DO229050	LICA	ICGC	EKENN	DEG_APCC_KENBOX_2	0.1944
p.S77Y	ACH-001028	Rhabdoid	CCLE	EKENN	DEG_APCC_KENBOX_2	0.1111
p.C61F	NCI-H2227	lung	COSMIC	EKENN	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A2RUB6	Coiled-coil domain-containing protein 66	DEG_APCC_KENBOX_2	671:675	EKENN	APC,CDC20,FZR1	0.9644	More...
Q6P0N0	Mis18-binding protein 1	DEG_APCC_KENBOX_2	166:170	EKENN	APC,CDC20,FZR1	0.8428	More...
Q9Y2K7	Lysine-specific demethylase 2A	DEG_APCC_KENBOX_2	775:779	EKENN	APC,CDC20,FZR1	0.9666	More...
Q6ZMT9	Death domain-containing protein 1	DEG_APCC_KENBOX_2	65:69	EKENN	APC,CDC20,FZR1	0.9955	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons