DegronMD

Uniprot ID: Q6P0N0

Source protein: Mis18-binding protein 1

Source gene: MIS18BP1

Class: DEG_APCC_KENBOX_2

Location: 166:170

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8428

ASA_SCORE: 99.94

COIL: 0.6366

CONS_SCORE: 0.2898

DSS_SCORE: 0.5103

HELIX: 0.3054

FCONS_SCORE: 0.8821

RIG_SCORE: 0.7208

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S172L	TCGA-21-1071	LUSC	TCGA	EKENN	DEG_APCC_KENBOX_2	0.7222
p.S172L	DO26918	LUSC	ICGC	EKENN	DEG_APCC_KENBOX_2	0.7222
p.K171N	TCGA-D1-A17Q	UCEC	TCGA	EKENN	DEG_APCC_KENBOX_2	0.75
p.K171N	DO41903	UCEC	ICGC	EKENN	DEG_APCC_KENBOX_2	0.75
p.K157T	TCGA-EY-A1G8	UCEC	TCGA	EKENN	DEG_APCC_KENBOX_2	0.5278
p.K157T	DO43578	UCEC	ICGC	EKENN	DEG_APCC_KENBOX_2	0.5278
p.T161N	DO229029	LICA	ICGC	EKENN	DEG_APCC_KENBOX_2	0.6389
p.L158M	DO229047	LICA	ICGC	EKENN	DEG_APCC_KENBOX_2	0.1111
p.L158M	DO229049	LICA	ICGC	EKENN	DEG_APCC_KENBOX_2	0.1111
p.K167N	SIDM00683	Prostate Carcinoma	GDSC	EKENN	DEG_APCC_KENBOX_2	0.6918
p.K167N	ACH-000977	lymph_node	CCLE	EKENN	DEG_APCC_KENBOX_2	0.6918
p.K157N	SIDM01016	T-Lymphoblastic Leukemia	GDSC	EKENN	DEG_APCC_KENBOX_2	0.5278
p.K157N	SIDM00120	Prostate Carcinoma	GDSC	EKENN	DEG_APCC_KENBOX_2	0.5278
p.K157N	SIDM00500	Colorectal Carcinoma	GDSC	EKENN	DEG_APCC_KENBOX_2	0.5278
p.C164R	SIDM00672	Hepatocellular Carcinoma	GDSC	EKENN	DEG_APCC_KENBOX_2	0.2778
p.C164R	SIDM00773	Non-Cancerous	GDSC	EKENN	DEG_APCC_KENBOX_2	0.2778
p.C164R	SIDM00807	Bladder Carcinoma	GDSC	EKENN	DEG_APCC_KENBOX_2	0.2778
p.C164R	SIDM00774	Breast Carcinoma	GDSC	EKENN	DEG_APCC_KENBOX_2	0.2778
p.K156I	SIDM01171	Glioblastoma	GDSC	EKENN	DEG_APCC_KENBOX_2	0.1667
p.K156I	ACH-000571	Brain Cancer	CCLE	EKENN	DEG_APCC_KENBOX_2	0.1667
p.K156I	T98G	central_nervous_system	COSMIC	EKENN	DEG_APCC_KENBOX_2	0.1667
p.K156N	SIDM00323	B-Cell Non-Hodgkin's Lymphoma	GDSC	EKENN	DEG_APCC_KENBOX_2	0.1667
p.K156N	TK	haematopoietic_and_lymphoid_tissue	COSMIC	EKENN	DEG_APCC_KENBOX_2	0.1667
p.D176G	SIDM00699	Small Cell Lung Carcinoma	GDSC	EKENN	DEG_APCC_KENBOX_2	0.1667
p.D176G	ACH-001138	Lung Cancer	CCLE	EKENN	DEG_APCC_KENBOX_2	0.1667
p.D176G	NCI-H2141	lung	COSMIC	EKENN	DEG_APCC_KENBOX_2	0.1667
p.Q159R	SIDM01608	Endometrial Carcinoma	GDSC	EKENN	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A2RUB6	Coiled-coil domain-containing protein 66	DEG_APCC_KENBOX_2	671:675	EKENN	APC,CDC20,FZR1	0.9644	More...
Q6P0N0	Mis18-binding protein 1	DEG_APCC_KENBOX_2	166:170	EKENN	APC,CDC20,FZR1	0.8428	More...
Q9Y2K7	Lysine-specific demethylase 2A	DEG_APCC_KENBOX_2	775:779	EKENN	APC,CDC20,FZR1	0.9666	More...
Q6ZMT9	Death domain-containing protein 1	DEG_APCC_KENBOX_2	65:69	EKENN	APC,CDC20,FZR1	0.9955	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: EKENN

Degron related mutations and impact score

Drug responses associated with MIS18BP1 mutations

All proteins holding degron of EKENN