DegronMD

Uniprot ID: Q6ZMT9

Source protein: Death domain-containing protein 1

Source gene: DTHD1

Class: DEG_APCC_DBOX_1

Location: 24:32

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7363

ASA_SCORE: 78.4333

COIL: 0.4439

CONS_SCORE: 0.3609

DSS_SCORE: 0.4528

HELIX: 0.0829

FCONS_SCORE: 1.1258

RIG_SCORE: 0.7618

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G26R	DO229010	COCA	ICGC	ARGELNVIE	DEG_APCC_DBOX_1	0.6457
p.G26R	DO229016	COCA	ICGC	ARGELNVIE	DEG_APCC_DBOX_1	0.6457
p.V14D	DO229010	COCA	ICGC	ARGELNVIE	DEG_APCC_DBOX_1	0.0556
p.V14D	DO229013	COCA	ICGC	ARGELNVIE	DEG_APCC_DBOX_1	0.0556
p.V14D	DO229016	COCA	ICGC	ARGELNVIE	DEG_APCC_DBOX_1	0.0556
p.V14D	DO229003	COCA	ICGC	ARGELNVIE	DEG_APCC_DBOX_1	0.0556
p.V14D	DO229005	COCA	ICGC	ARGELNVIE	DEG_APCC_DBOX_1	0.0556
p.V14I	DO225404	LAML	ICGC	ARGELNVIE	DEG_APCC_DBOX_1	0.0556
p.V14I	KYSE-140	oesophagus	COSMIC	ARGELNVIE	DEG_APCC_DBOX_1	0.0556
p.V14I	SNU-1040	large_intestine	COSMIC	ARGELNVIE	DEG_APCC_DBOX_1	0.0556
p.V14I	NEC8	testis	COSMIC	ARGELNVIE	DEG_APCC_DBOX_1	0.0556
p.V14I	NUGC-4	stomach	COSMIC	ARGELNVIE	DEG_APCC_DBOX_1	0.0556
p.V14I	TGBC24TKB	biliary_tract	COSMIC	ARGELNVIE	DEG_APCC_DBOX_1	0.0556
p.V14F	DO228948	LICA	ICGC	ARGELNVIE	DEG_APCC_DBOX_1	0.0556
p.E32K	DO222702	MELA	ICGC	ARGELNVIE	DEG_APCC_DBOX_1	0.591
p.H20Q	DO38404	STAD	ICGC	ARGELNVIE	DEG_APCC_DBOX_1	0.2222
p.N39H	DO43186	UCEC	ICGC	ARGELNVIE	DEG_APCC_DBOX_1	0.1389
p.I37K	ACH-001715	Bone Cancer	CCLE	ARGELNVIE	DEG_APCC_DBOX_1	0.1944
p.I37K	CAL-72	bone	COSMIC	ARGELNVIE	DEG_APCC_DBOX_1	0.1944
p.L30Q	HARA	lung	COSMIC	ARGELNVIE	DEG_APCC_DBOX_1	0.7765
p.L30P	EW-7	bone	COSMIC	ARGELNVIE	DEG_APCC_DBOX_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6ZMT9	Death domain-containing protein 1	DEG_APCC_DBOX_1	24:32	ARGELNVIE	APC,CDC20,FZR1	0.7363	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons